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Literature summary extracted from

  • Bedernjak, A.F.; Zaytsev, A.V.; Babolat, M.; Cellier, M.; James, A.L.; Orenga, S.; Perry, J.D.; Groundwater, P.W.; Anderson, R.J.
    Synthesis and evaluation of novel 7- and 8-aminophenoxazinones for the detection of beta-alanine aminopeptidase activity and the reliable identification of Pseudomonas aeruginosa in clinical samples (2016), J. Med. Chem., 59, 4476-4487 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.11.2 analysis synthesis of chromogenic selective beta-alanyl aminopeptidase substrates, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation. The compounds display sensitivity to a wider range of Pseudomonas aeruginosa strains tested Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Pseudomonas aeruginosa
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 7-N-(beta-alanyl)amino-2-pentyl-3H-phenoxazin-3-one + H2O compound displays selective beta-alanyl aminopeptidase sensitivity, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation Pseudomonas aeruginosa beta-alanine + 7-amino-2-pentyl-3H-phenoxazin-3-one
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3.4.11.2 8-N-(beta-alanyl)amino-2-butyl-3H-phenoxazin-3-one + H2O compound displays selective beta-alanyl aminopeptidase sensitivity, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation Pseudomonas aeruginosa beta-alanine + 8-amino-2-butyl-3H-phenoxazin-3-one
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3.4.11.2 8-N-(beta-alanyl)amino-2-pentyl-3H-phenoxazin-3-one + H2O compound displays selective beta-alanyl aminopeptidase sensitivity, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation Pseudomonas aeruginosa beta-alanine + 8-amino-2-pentyl-3H-phenoxazin-3-one
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