EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.1.99 | medicine | inhibition of fatty acid amide hydrolasis is considered a powerful approach to enhance the endocannabinoid signalling and is a potential target for the treatment of neurological disorders such as anxiety or depression, or of inflammatory process | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.99 | 1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide | - |
Rattus norvegicus | |
3.5.1.99 | 1-(4-benzylpiperazin-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one | 18% inhibition at 0.1 mM | Rattus norvegicus | |
3.5.1.99 | 1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-(2-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | 33% inhibition at 0.1 mM | Rattus norvegicus | |
3.5.1.99 | 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-(3-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | 41% inhibition at 0.1 mM | Rattus norvegicus | |
3.5.1.99 | 1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 1-[4-[(3-chlorophenyl)methyl]piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | 8% inhibition at 0.1 mM | Rattus norvegicus | |
3.5.1.99 | 2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one | - |
Rattus norvegicus | |
3.5.1.99 | 2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide | - |
Rattus norvegicus | |
3.5.1.99 | 2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | 2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide | - |
Rattus norvegicus | |
3.5.1.99 | N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(2,6-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | 19% inhibition at 0.1 mM | Rattus norvegicus | |
3.5.1.99 | N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | - |
Rattus norvegicus | |
3.5.1.99 | N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea | - |
Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.99 | Rattus norvegicus | P97612 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.99 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.99 | N-arachidonoylethanolamine + H2O | - |
Rattus norvegicus | arachidonic acid + ethanolamine | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.5.1.99 | 0.0017 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.0017 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.0017 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.0041 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.0044 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.0045 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.0047 | - |
37°C, pH 7.4 | Rattus norvegicus | 2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one | |
3.5.1.99 | 0.0052 | - |
37°C, pH 7.4 | Rattus norvegicus | 2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide | |
3.5.1.99 | 0.016 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.016 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.017 | - |
37°C, pH 7.4 | Rattus norvegicus | 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one | |
3.5.1.99 | 0.018 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.018 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.021 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.021 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea | |
3.5.1.99 | 0.025 | - |
37°C, pH 7.4 | Rattus norvegicus | 1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide | |
3.5.1.99 | 0.027 | - |
37°C, pH 7.4 | Rattus norvegicus | N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide | |
3.5.1.99 | 0.027 | - |
37°C, pH 7.4 | Rattus norvegicus | N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide | |
3.5.1.99 | 0.028 | - |
37°C, pH 7.4 | Rattus norvegicus | 2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide | |
3.5.1.99 | 0.036 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.043 | - |
37°C, pH 7.4 | Rattus norvegicus | N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide | |
3.5.1.99 | 0.051 | - |
37°C, pH 7.4 | Rattus norvegicus | 2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.5.1.99 | physiological function | the enzyme plays a key role in controlling endogenous levels of endocannabinoids | Rattus norvegicus |