EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B4 | CL-82198 | - |
Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B4 | Danio rerio | - |
- |
- |
3.4.24.B4 | Mus musculus | P33435 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B4 | MMP13a | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.24.B4 | physiological function | in a larval zebrafish model, glucose treatment induces sensory axon degeneration, which is mediated by ROS formation in the skin, and ROS-dependent MMP13 activation. Glucose-induced sensory axon degeneration is prevented upon pharmacological inhibition of ROS with N-acetylcysteine, and upon pharmacological MMP13 inhibition | Danio rerio |
3.4.24.B4 | physiological function | neuropathy is reversed upon injection of MMP13 inhibitor into obese mice on a high-fat/high sugar diet | Mus musculus |