Literature summary extracted from

Mandal, R.; Das, S.
In silico approach towards identification of potential inhibitors of Helicobacter pylori DapE (2015), J. Biomol. Struct. Dyn., 33, 1460-1473 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.1.18	additional information	Tanimoto-based similarity searching in the PubChem Database with DapE substrate N-succinyl-LL-2,6-diaminoheptanedioate as a query molecule, followed by fragment-based docking approach using GLIDE XP identifies two potential substrate-competitive small molecule inhibitors of DapE. These new molecules may provide a starting point to search for novel therapeutics	Helicobacter pylori

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.18	Helicobacter pylori	O25002	-	-
3.5.1.18	Helicobacter pylori ATCC 700392	O25002	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.1.18	DapE	-	Helicobacter pylori
3.5.1.18	N-succinyl-L,L-diaminopimelic acid desuccinylase	-	Helicobacter pylori

General Information

EC Number	General Information	Comment	Organism
3.5.1.18	malfunction	deletion of the DapE gene is lethal to Helicobacter pylori, since the organism has no alternative pathway for lysine biosynthesis	Helicobacter pylori
3.5.1.18	physiological function	critical enzyme of the lysine biosynthetic pathway	Helicobacter pylori

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Release 2023.1 (January 2023)