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Literature summary extracted from

  • South, K.; Freitas, M.O.; Lane, D.A.
    A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor (2017), J. Biol. Chem., 292, 5760-5769 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.87 von Willebrand factor the enzyme is conformationally activated by von Willebrand factor which engages the TSP8-CUB2 domains, inducing the conformational change that disrupts the CUB1-spacer domain interaction and thereby activates the enzyme Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.87 568K/F592Y/R660K/Y661F/Y665F the mutant shows enhanced proteolytic activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 FRETS-von Willebrand factor 73 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.87 von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 a disintegrin and metalloprotease with thrombospondin motifs 13
-
 Homo sapiens
3.4.24.87 ADAMTS13
-
 Homo sapiens