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Literature summary extracted from

  • Kong, L.; Shaw, N.; Yan, L.; Lou, Z.; Rao, Z.
    Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus (2015), J. Biol. Chem., 290, 7160-7168 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.B14 expression in Escherichia coli infectious bronchitis virus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.22.B14 to 2.15 A resolution. PLpro has a short blocking loop BL1-like loop. Access to a conserved catalytic triad consisting of Cys101, His264, and Asp275 is regulated by the flexible loop BL2 infectious bronchitis virus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B14 infectious bronchitis virus P0C6Y1
-
-
3.4.22.B14 infectious bronchitis virus Beaudette P0C6Y1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B14 KAGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus KAGG + 7-amino-4-methylcoumarin
-
 ?
3.4.22.B14 KAGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus Beaudette KAGG + 7-amino-4-methylcoumarin
-
 ?
3.4.22.B14 KKAG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus KKAG + 7-amino-4-methylcoumarin
-
 ?
3.4.22.B14 KKAG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus Beaudette KKAG + 7-amino-4-methylcoumarin
-
 ?
3.4.22.B14 LRGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus LRGG + 7-amino-4-methylcoumarin
-
 ?
3.4.22.B14 LRGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus Beaudette LRGG + 7-amino-4-methylcoumarin
-
 ?
3.4.22.B14 Lys48-Ub4 + H2O
-
 infectious bronchitis virus ?
-
 ?
3.4.22.B14 Lys48-Ub4 + H2O
-
 infectious bronchitis virus Beaudette ?
-
 ?
3.4.22.B14 Lys63-Ub4 + H2O
-
 infectious bronchitis virus ?
-
 ?
3.4.22.B14 additional information PLpro can degrade Lys48- and Lys63-linked polyubiquitin chains to monoubiquitin but not linear polyubiquitin infectious bronchitis virus ?
-
 ?
3.4.22.B14 additional information PLpro can degrade Lys48- and Lys63-linked polyubiquitin chains to monoubiquitin but not linear polyubiquitin infectious bronchitis virus Beaudette ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B14 PLpro
-
 infectious bronchitis virus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.4.22.B14 0.67
-
 KKAG-7-amido-4-methylcoumarin pH 7.5, 25°C infectious bronchitis virus
3.4.22.B14 3.23
-
 KAGG-7-amido-4-methylcoumarin pH 7.5, 25°C infectious bronchitis virus