EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.297 | FTY720 | FTY720 is an effective immunomodulatory molecule and is a competitive inhibitor of ceramide synthase 2 toward dihydrosphingosine, it shows interference with sphingolipid de novo biosynthesis, overview. The inhibition of CerS2 activity is reversible as the potency of inhibition diminishes with the dilution of the enzyme-inhibitor preparation | Homo sapiens | |
2.3.1.297 | fumonisin B1 | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.297 | 0.0000677 | - |
behenoyl-CoA | pH 7.4, 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.297 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.297 | lung | - |
Homo sapiens | - |
2.3.1.297 | pulmonary artery endothelial cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.297 | D-erythro-sphinganine + behenoyl-CoA | - |
Homo sapiens | N-behenoyl-D-sphinganine + CoA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.297 | ceramide synthase 2 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.297 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.297 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.297 | 0.00215 | - |
FTY720 | pH 7.4, 37°C | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.297 | 0.0064 | - |
pH 7.4, 37°C | Homo sapiens | FTY720 |