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Literature summary extracted from
- Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta (2003), J. Biol. Chem., 278, 49438-49447 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.111 | expression in Sf9 cell, HeLa cell, CHO-K1 cell | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.1.1.111 | S159A | inactive | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.111 | vanadate | completely inhibits the activity, EC50 value 0.01 mM | Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.111 | plasma membrane | - |
Homo sapiens | 5886 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.111 | Homo sapiens | Q6XZB0 | testis-specific isoform PS-PLAbeta | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.111 | membrane-associated mPA-PLA1 is insoluble in solubilization by 1% Triton X-100 and is detected in Triton X-100-insoluble buoyant fractions of sucrose gradients | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.111 | testis | specifically expressed in testis | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.111 | 1-palmitoyl-2-oleoyl-sn-glycero-phosphatic acid + H2O | - |
Homo sapiens | 2-oleyl-1-lysophosphatidic acid + palmitate | - |
? | |
| 3.1.1.111 | phosphatidic acid + H2O | - |
Homo sapiens | lysophosphatidic acid + a fatty acid | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.111 | ? | x * 55000, SDS-PAGE, recombinant protein | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.111 | lipase member I | - |
Homo sapiens |
| 3.1.1.111 | LIPI | - |
Homo sapiens |
| 3.1.1.111 | PS-PLA1beta | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.1.111 | physiological function | isoform Ps-PLA1beta shows high affinity to heparin | Homo sapiens |
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Release 2023.1 (January 2023)
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