Literature summary extracted from

Hosono, H.; Aoki, J.; Nagai, Y.; Bandoh, K.; Ishida, M.; Taguchi, R.; Arai, H.; Inoue, K.
Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine (2001), J. Biol. Chem., 276, 29664-29670 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.1.111	a 1-acyl-2-lyso-phosphatidylserine + H2O	Rattus norvegicus	-	glycerophosphoserine + a fatty acid	-	?
3.1.1.111	a phosphatidylserine + H2O	Rattus norvegicus	-	a 2-acyl-1-lyso-phosphatidylserine + a fatty acid	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.111	Rattus norvegicus	P97535	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.111	a 1-acyl-2-lyso-phosphatidylserine + H2O	-	Rattus norvegicus	glycerophosphoserine + a fatty acid	-	?
3.1.1.111	a phosphatidylserine + H2O	-	Rattus norvegicus	a 2-acyl-1-lyso-phosphatidylserine + a fatty acid	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.111	PLA1	-	Rattus norvegicus
3.1.1.111	PS-PLA1	-	Rattus norvegicus

General Information

EC Number	General Information	Comment	Organism
3.1.1.111	physiological function	enzyme stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lyso-phosphatidylserine in the presence of FcepsilonRI cross-linker. The potency of 2-acyl-1-lyso-phosphatidylserine is almost equal to that of 1-acyl-2-lyso-phosphatidylserine. The enzyme stimulates the histamine release more efficiently when rat peritoneal mast cells are mixed with apoptotic Jurkat cells. Heparin has affinity for PS-PLA1 and completely blocks the stimulatory effect of the enzyme	Rattus norvegicus

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Release 2023.1 (January 2023)