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Literature summary extracted from

  • Tachibana, M.; Sugimoto, K.; Fukushima, T.; Shinkai, Y.
    Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3 (2001), J. Biol. Chem., 276, 25309-25317 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.355 expressed in Escherichia coli BL21 codon-plus RIL cells Homo sapiens
2.1.1.356 expressed in Escherichia coli BL21 codon-plus RIL cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.355 nucleus
-
 Homo sapiens 5634
-
2.1.1.356 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?
2.1.1.356 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Homo sapiens Q96KQ7
-
-
2.1.1.356 Homo sapiens Q96KQ7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 HEK-293 cell
-
 Homo sapiens
-
2.1.1.356 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 additional information the enzyme is able to add methyl groups to lysine 27 as well as 9 in histone H3 Homo sapiens ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?
2.1.1.356 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 additional information the enzyme is able to add methyl groups to lysine 27 as well as 9 in histone H3 Homo sapiens ?
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-L-lysine27
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 G9a
-
 Homo sapiens
2.1.1.355 lysine-preferring HMTase
-
 Homo sapiens
2.1.1.356 G9a
-
 Homo sapiens
2.1.1.356 lysine-preferring HMTase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.355 physiological function the enzyme contributes to the regulation of chromatin structure Homo sapiens
2.1.1.356 physiological function the enzyme contributes to the regulation of chromatin structure Homo sapiens