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Literature summary extracted from

  • Nagai, Y.; Aoki, J.; Sato, T.; Amano, K.; Matsuda, Y.; Arai, H.; Inoue, K.
    An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans (1999), J. Biol. Chem., 274, 11053-11059 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.111 a 1-acyl-2-lyso-phosphatidylserine + H2O Homo sapiens
-
 glycerophosphoserine + a fatty acid
-
 ?
3.1.1.111 a phosphatidylserine + H2O Homo sapiens
-
 a 2-acyl-1-lyso-phosphatidylserine + a fatty acid
-
 ?
3.1.1.111 additional information Homo sapiens an alternative splicing 376-amino acid product lacks two-thirds of the C-terminal domain of PS-PLA1 hydrolyzes exclusively lyso-phosphatidylserine but not phosphatidylserine appreciably. Phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, and their lyso derivatives are not hydrolyzed at all by the variant ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.111 Homo sapiens Q53H76 existence of two alternative splicing forms
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.111 additional information mRNAs for both wild-type and splicing variant are detected in human fibroblast, keratinocyte, melanoma, HepG2, and HeLa cells Homo sapiens
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3.1.1.111 additional information transcripts are detected in various human tissues, including skeletal muscle, kidney, small intestine, spleen, and testis. The amount of the splicing variant in these tissues is about 10 to 20% that of the wild-type Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.111 1-oleoyl-2-lyso-phosphatidic acid + H2O
-
 Homo sapiens sn-glycerol-1-phosphate + oleate
-
 ?
3.1.1.111 1-oleoyl-2-lyso-phosphatidylcholine + H2O
-
 Homo sapiens glycerophosphocholine + oleate
-
 ?
3.1.1.111 1-oleoyl-2-lyso-phosphatidylethanolamine + H2O
-
 Homo sapiens glycerophosphoethanolamine + oleate
-
 ?
3.1.1.111 1-oleoyl-2-lyso-phosphatidylserine + H2O
-
 Homo sapiens glycerophosphoserine + oleate
-
 ?
3.1.1.111 a 1-acyl-2-lyso-phosphatidylserine + H2O
-
 Homo sapiens glycerophosphoserine + a fatty acid
-
 ?
3.1.1.111 a phosphatidylserine + H2O
-
 Homo sapiens a 2-acyl-1-lyso-phosphatidylserine + a fatty acid
-
 ?
3.1.1.111 additional information an alternative splicing 376-amino acid product lacks two-thirds of the C-terminal domain of PS-PLA1 hydrolyzes exclusively lyso-phosphatidylserine but not phosphatidylserine appreciably. Phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, and their lyso derivatives are not hydrolyzed at all by the variant Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.111 PLA1
-
 Homo sapiens
3.1.1.111 PS-PLA1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.111 physiological function both wild-type and the natural splicing variant bind to heparin. The heparin binding site is located in N-terminal region of the enzyme Homo sapiens