Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wang, E.; Norred, W.P.; Bacon, C.W.; Riley, R.T.; Merrill, A.H.
    Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme (1991), J. Biol. Chem., 266, 14486-14490 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.24 fumonisin B1 complete inhibition in vivo and in vitro Rattus norvegicus
2.3.1.24 additional information fumonisins isolated from Fusarium moniliforme inhibit the conversion of sphinganine to N-acyl-sphinganines and the activity of sphingosine N-acyltransferase (ceramide synthase). No inhibiton of serine palmitoyltransferase by fumonisin B1 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.24 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.24 sphingosine + palmitoyl-CoA Rattus norvegicus
-
 N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA Rattus norvegicus Sprague-Dawley
-
 N-palmitoylsphingosine + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.24 Rattus norvegicus
-
-
-
2.3.1.24 Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.24 hepatocyte
-
 Rattus norvegicus
-
2.3.1.24 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.24 additional information the conversion of [14C]sphinganine to N-acyl-[14C]sphinganines Rattus norvegicus ?
-
 ?
2.3.1.24 additional information the conversion of [14C]sphinganine to N-acyl-[14C]sphinganines Rattus norvegicus Sprague-Dawley ?
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA
-
 Rattus norvegicus N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA
-
 Rattus norvegicus Sprague-Dawley N-palmitoylsphingosine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.24 ceramide synthase
-
 Rattus norvegicus
2.3.1.24 sphingosine N-acyltransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.24 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.24 7.4
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.24 0.0001
-
 pH 7.4, 37°C Rattus norvegicus fumonisin B1

General Information

EC Number General Information Comment Organism
2.3.1.24 malfunction disruption of the de novo pathway of sphingolipid biosynthesis may be a critical in the diseases that have been associated with consumption of fumonisins. Fusarium moniliforme causes equine leucoencephalomalacia, porcine pulmonary edem syndrome, and liver cancer in rats Rattus norvegicus
2.3.1.24 metabolism the conversion of sphinganine to N-acyl-sphinganines is thought to precede via introduction of the 4,5-trans double bond of sphingosine Rattus norvegicus