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Literature summary extracted from
- A comprehensive analysis of the peroxiredoxin reduction system in the cyanobacterium Synechocystis sp. strain PCC 6803 reveals that all five peroxiredoxins are thioredoxin dependent (2009), J. Bacteriol., 191, 7477-7489 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.11.1.24 | expression in Escherichia coli | Synechocystis sp. PCC 6803 |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.11.1.24 | 0.00074 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0009 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0021 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.00218 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0026 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0026 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0028 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0029 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0046 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0066 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0096 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0122 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0173 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.0208 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.24 | Synechocystis sp. PCC 6803 | P72697 | - |
- |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | P72719 | - |
- |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | P73263 | - |
- |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | P73728 | - |
- |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | Q55624 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.24 | - |
Synechocystis sp. PCC 6803 |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.24 | thioredoxin A + cumene hydroperoxide | - |
Synechocystis sp. PCC 6803 | thioredoxin A disulfide + H2O + cumene hydroxide | - |
? |  |
| 1.11.1.24 | thioredoxin A + H2O2 | - |
Synechocystis sp. PCC 6803 | thioredoxin A disulfide + 2 H2O | - |
? | |
| 1.11.1.24 | thioredoxin A + tert-butyl hydroperoxide | - |
Synechocystis sp. PCC 6803 | thioredoxin A disulfide + H2O + tert-butyl alcohol | - |
? | |
| 1.11.1.24 | thioredoxin B + H2O2 | - |
Synechocystis sp. PCC 6803 | thioredoxin B disulfide + 2 H2O | - |
? | |
| 1.11.1.24 | thioredoxin Q + H2O2 | - |
Synechocystis sp. PCC 6803 | thioredoxin Q disulfide + 2 H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.24 | 1-Cys Prx | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | 2-Cys Prx | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | Prx Q1 | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | Prx Q2 | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | PrxII | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | sll0221 | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | sll0755 | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | sll1621 | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | slr0242 | - |
Synechocystis sp. PCC 6803 |
| 1.11.1.24 | slr1198 | - |
Synechocystis sp. PCC 6803 |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.11.1.24 | 0.009 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.01 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.01 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.015 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.045 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.063 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.072 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.079 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.092 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.099 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 0.212 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.11.1.24 | Synechocystis sp. PCC 6803 | following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels | down |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels | up |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels. Induction of the 2-cys prx gene in response to high light intensity | up |
| 1.11.1.24 | Synechocystis sp. PCC 6803 | following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels. The transcript level of the prxII gene increases during nitrogen starvation | up |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.11.1.24 | 2 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 2 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 3 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 6 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 9.7 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 10 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 11 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 13 | - |
thioredoxin B | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 22 | - |
thioredoxin A | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 39 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 54 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 | |
| 1.11.1.24 | 85 | - |
thioredoxin Q | pH 7.0, temperature not specified in the publication | Synechocystis sp. PCC 6803 |
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