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Literature summary extracted from

  • Junghare, M.; Spiteller, D.; Schink, B.
    Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans (2019), ISME J., 13, 1252-1268 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.118 EDTA
-
 Syntrophorhabdus aromaticivorans

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.118 Syntrophorhabdus aromaticivorans
-
-
-
6.2.1.58 Syntrophorhabdus aromaticivorans
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.58 0.073
-
 cell-free extract, pH 7.6, temperature not specified in the publication Syntrophorhabdus aromaticivorans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.118 isophthalyl-CoA
-
 Syntrophorhabdus aromaticivorans benzoyl-CoA + CO2
-
 ?
4.1.1.118 additional information no substrates: o-phthalyl-CoA and terephthalyl-CoA Syntrophorhabdus aromaticivorans ?
-
 ?
6.2.1.58 ATP + isophthalate + CoA
-
 Syntrophorhabdus aromaticivorans AMP + diphosphate + isophthalyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.118 IPCD
-
 Syntrophorhabdus aromaticivorans
6.2.1.58 IPCL
-
 Syntrophorhabdus aromaticivorans

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.118 FMN prenylated FMN Syntrophorhabdus aromaticivorans

Expression

EC Number Organism Comment Expression
6.2.1.58 Syntrophorhabdus aromaticivorans expression is specifically induced by growth on isophthalate up

General Information

EC Number General Information Comment Organism
4.1.1.118 physiological function in isophthalate-grown cells, isophthalate is activated to isophthalyl-CoA by an ATP-dependent isophthalate:CoA ligase (IPCL, EC 6.2.1.58), and subsequently decarboxylated to benzoyl-CoA by UbiD family isophthalyl-CoA decarboxylase (IPCD) that requires a prenylated flavin mononucleotide cofactor supplied by UbiX to effect decarboxylation Syntrophorhabdus aromaticivorans
6.2.1.58 physiological function in isophthalate-grown cells, isophthalate is activated to isophthalyl-CoA by ATP-dependent isophthalate:CoA ligase, and subsequently decarboxylated to benzoyl-CoA by UbiD family isophthalyl-CoA decarboxylase (IPCD, EC 4.1.1.118) that requires a prenylated flavin mononucleotide cofactor supplied by UbiX to effect decarboxylation Syntrophorhabdus aromaticivorans