Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kebe, N.M.; Samanta, K.; Singh, P.; Lai-Kee-Him, J.; Apicella, V.; Payrot, N.; Lauraire, N.; Legrand, B.; Lisowski, V.; Mbang-Benet, D.E.; Pages, M.; Bastien, P.; Kajava, A.V.; Bron, P.; Hernandez, J.F.; Coux, O.
    The HslV protease from Leishmania major and its activation by C-terminal HslU peptides (2019), Int. J. Mol. Sci., 20, 1021 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.25.2 additional information protease HslV can be activated by peptides derived from the C-termini of both ATPase isoforms HslU1 and HslU2. Five out of the six C-terminal residues of HslU2 are essential for binding to and activating HslV. Dodecapeptides derived from HslU of other parasites and bacteria are able to activate HslV with similar or even higher efficiency Leishmania major

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.4.25.2 Leishmania major A4HWA6 subunit HslU1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.25.2 benzyloxycarbonyl-EVNL-7-amido-4-methylcoumarin + H2O
-
 Leishmania major benzyloxycarbonyl-EVNL + 7-amino-4-methylcoumarin
-
 ?
3.4.25.2 benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin + H2O
-
 Leishmania major benzyloxycarbonyl-GGL + 7-amino-4-methylcoumarin
-
 ?
3.4.25.2 succinyl-LLVY-7-amido-4-methylcoumarin + H2O
-
 Leishmania major succinyl-LLVY + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.25.2 LINF_150005800 gene name, isoform HslU1 Leishmania major

General Information

EC Number General Information Comment Organism
3.4.25.2 physiological function protease HslV can be activated by peptides derived from the C-termini of both ATPase isoforms HslU1 and HslU2. Five out of the six C-terminal residues of HslU2 are essential for binding to and activating HslV. Dodecapeptides derived from HslU of other parasites and bacteria are able to activate HslV with similar or even higher efficiency Leishmania major