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Literature summary extracted from

  • Xu, H.; Zhang, H.; Ding, Y.
    Platelet-derived growth factor and stromal cell-derived factor-1 promote the skin wound repairing effect of bone mesenchymal stem cells a key role of matrix metalloproteinase 1 and collagens (2017), Int. J. Clin. Exp. Pathol., 10, 8253-8262 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.7 additional information platelet-derived growth factor (PDGF) treatment recruits BSMCs to injured sites and strengthens the effect of BMSCs on skin wound by suppressing activity of MMP-1 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.7 Collagen + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.24.7 Collagen + H2O Rattus norvegicus Sprague-Dawley
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.7 Rattus norvegicus B5DFD5
-
-
3.4.24.7 Rattus norvegicus Sprague-Dawley B5DFD5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.7 bone
-
 Rattus norvegicus
-
3.4.24.7 mesenchymal stem cell of bone marrow Rattus norvegicus
-
3.4.24.7 skin
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.7 Collagen + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.7 Collagen + H2O
-
 Rattus norvegicus Sprague-Dawley ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.7 matrix metalloproteinase 1
-
 Rattus norvegicus
3.4.24.7 MMP-1
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.24.7 metabolism matrix metalloproteinase 1 and collagens play a key role in platelet-derived growth factor (PDGF) and stromal cell-derived factor-1 (SDF-1) promotion of the skin wound repairing effect of bone mesenchymal stem cells. Bone marrow mesenchymal stem cells (BMSCs) are applied to treatment of skin wounds. PDGF treatment recruits BSMCs to injured sites and strengthens the effect of BMSCs on skin wound by suppressing activity of MMP-1. SDF-1 treatment increases the treating effect of BMSCs on skin injury through the deposition of collagen I and collagen III. Phenotypes, overview Rattus norvegicus