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Literature summary extracted from

  • Samykannu, G.; Vijayababu, P.; Natarajan, J.
    Substrate specificities in Salmonella typhi outer membrane protease (PgtE) from omptin family - an in silico proteomic approach (2018), Inform. Med. Unlocked, 12, 6-13 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.23.49 gene pgtE, DNA and amino acid sequence determination and analysis Salmonella enterica subsp. enterica serovar Typhi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.49 amprenavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 atazanavir sulfate
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 Cu2+ enzyme binding study Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 darunavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 diisopropyl fluorophosphates
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 fosamprenavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 indinavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 Mg2+ enzyme binding study Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 additional information molecular docking study with protease inhibitors, overview. No interaction with lopinavir and tipranavir Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 nelfinavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 pepstatin
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 phenylmethylsulfonyl fluoride
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 ritonavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 saquinavir
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 Zn2+ enzyme binding study Salmonella enterica subsp. enterica serovar Typhi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.23.49 additional information metal ion docking studies, Mg2+ has better interaction with enzyme PgtE compared to Zn2+ and Cu2+ ions Salmonella enterica subsp. enterica serovar Typhi

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.49 Salmonella enterica subsp. enterica serovar Typhi Q8Z4Y4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.49 additional information substrate specificity of PgtE, determination of cleavage sites and sequences, overview Salmonella enterica subsp. enterica serovar Typhi ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.49 outer membrane protease
-
Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 PgtE
-
Salmonella enterica subsp. enterica serovar Typhi

General Information

EC Number General Information Comment Organism
3.4.23.49 evolution the enzyme belongs to the omptin family of enzymes Salmonella enterica subsp. enterica serovar Typhi
3.4.23.49 additional information PgtE three-dimensional structure homology modelling using structure with PDB ID 1I78 as a template. Residues Glu29, Leu30, His 208, Phe 215, Glu 217 and Ala 275 occupy the active site Salmonella enterica subsp. enterica serovar Typhi