EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.48 | SspC | - |
Staphylococcus aureus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.48 | Galectin-3 + H2O | Staphylococcus aureus | the enzyme has galectin-3-processing capacity | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | Staphylococcus aureus | the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | Staphylococcus aureus NCTC 8325 | the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | Staphylococcus aureus NCTC 8325 | the enzyme has galectin-3-processing capacity | ? | - |
? | |
3.4.24.29 | Galectin-3 + H2O | Staphylococcus aureus | the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain | ? | - |
? | |
3.4.24.29 | Galectin-3 + H2O | Staphylococcus aureus NCTC 8325 | the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.19 | Staphylococcus aureus | Q2FZL2 | - |
- |
3.4.21.19 | Staphylococcus aureus NCTC 8325 | Q2FZL2 | - |
- |
3.4.22.48 | Staphylococcus aureus | Q2FZL3 | - |
- |
3.4.22.48 | Staphylococcus aureus | Q2G2R8 | - |
- |
3.4.22.48 | Staphylococcus aureus NCTC 8325 | Q2FZL3 | - |
- |
3.4.22.48 | Staphylococcus aureus NCTC 8325 | Q2G2R8 | - |
- |
3.4.24.29 | Staphylococcus aureus | Q2FZL2 | - |
- |
3.4.24.29 | Staphylococcus aureus NCTC 8325 | Q2FZL2 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.19 | additional information | the enzyme shows little or no degradation of galectin-3 | Staphylococcus aureus | ? | - |
? | |
3.4.21.19 | additional information | the enzyme shows little or no degradation of galectin-3 | Staphylococcus aureus NCTC 8325 | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | the enzyme has galectin-3-processing capacity | Staphylococcus aureus | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection | Staphylococcus aureus | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection | Staphylococcus aureus NCTC 8325 | ? | - |
? | |
3.4.22.48 | Galectin-3 + H2O | the enzyme has galectin-3-processing capacity | Staphylococcus aureus NCTC 8325 | ? | - |
? | |
3.4.24.29 | Galectin-3 + H2O | the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain | Staphylococcus aureus | ? | - |
? | |
3.4.24.29 | Galectin-3 + H2O | the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain | Staphylococcus aureus NCTC 8325 | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.19 | glutamyl endopeptidase | - |
Staphylococcus aureus |
3.4.21.19 | Sspa | - |
Staphylococcus aureus |
3.4.21.19 | V8 protease | - |
Staphylococcus aureus |
3.4.22.48 | SCPA | - |
Staphylococcus aureus |
3.4.22.48 | SspB | - |
Staphylococcus aureus |
3.4.22.48 | staphopain A | - |
Staphylococcus aureus |
3.4.22.48 | staphopain B | - |
Staphylococcus aureus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.22.48 | physiological function | SspB is a virulence factor. Its function is dependent on the presence of galectin-3. It inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. The enzyme is an inhibitor of galectin-3-mediated ROS production | Staphylococcus aureus |