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Literature summary extracted from

  • Kolesinska, B.; Wasko, J.; Kaminski, Z.; Geueke, B.; Kohler, H.; Seebach, D.
    Labeling and protecting N-terminal protein positions by beta-peptidyl aminopeptidase-catalyzed attachment of beta-amino-acid residues - insulin as a first example (2018), Helv. Chim. Acta, 101, e1700259 .
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.11.25 synthesis BapA catalyzes reversible protein acylation at the N-terminus. The selective modification can also be applied for protein labeling and tagging and should be generally useful, also to protect peptides and proteins from attack by common aminopeptidase Sphingosinicella xenopeptidilytica

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.25 Sphingosinicella xenopeptidilytica Q52VH2
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.25 insulin + rac-3-aminobutanamide enatioselectivity for beta-alanine is more than 300:1 Sphingosinicella xenopeptidilytica ?
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 r

Synonyms

EC Number Synonyms Comment Organism
3.4.11.25 BapA
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 Sphingosinicella xenopeptidilytica