EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.355 | additional information | the enzyme activity is stimulated by histone H2B Lys120 ubiquitination | Homo sapiens | |
2.1.1.360 | histone H2B ubiquitin | the enzyme activity is stimulated by histone H2B Lys120 ubiquitination | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.360 | expressed in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.355 | F326A | the mutant shows significantly reduced activity compared to the wild type enzyme | Homo sapiens |
2.1.1.355 | F326A | the mutation slightly decreases the enzyme activity | Homo sapiens |
2.1.1.355 | I290A | the mutant shows significantly reduced activity compared to the wild type enzyme | Homo sapiens |
2.1.1.355 | L284A | the mutant shows significantly reduced activity compared to the wild type enzyme | Homo sapiens |
2.1.1.355 | L329A | the mutant shows significantly reduced activity compared to the wild type enzyme | Homo sapiens |
2.1.1.355 | R282A | the mutation dramatically decreases the enzyme activity | Homo sapiens |
2.1.1.360 | F326A | the mutant shows significantly decreased enzyme activity compared to the wild type | Homo sapiens |
2.1.1.360 | I290A | the mutant shows significantly decreased enzyme activity compared to the wild type | Homo sapiens |
2.1.1.360 | L284A | the mutant shows significantly decreased enzyme activity compared to the wild type | Homo sapiens |
2.1.1.360 | R282A | the mutant shows dramatically decreased enzyme activity compared to the wild type | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.1.1.360 | nucleus | - |
Homo sapiens | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Homo sapiens | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + H2B ubiquitinated nucleosome | Homo sapiens | - |
? | - |
? | |
2.1.1.360 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 | Homo sapiens | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.355 | Homo sapiens | Q8TEK3 | - |
- |
2.1.1.360 | Homo sapiens | Q8TEK3 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.355 | glutahione S-transferase affinity column chromatography, anion exchange column chromatography, and gel filtration | Homo sapiens |
2.1.1.360 | glutahione S-transferase affinity column chromatography, cation exchange chromatography and S200 gel filtration | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | overall reaction | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + H2B ubiquitinated nucleosome | - |
Homo sapiens | ? | - |
? | |
2.1.1.360 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 | overall reaction | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.355 | DOT1L | - |
Homo sapiens |
2.1.1.355 | histone H3 Lys79 methyltransferase | - |
Homo sapiens |
2.1.1.360 | DOT1L | - |
Homo sapiens |
2.1.1.360 | histone H3 Lys79 methyltransferase | - |
Homo sapiens |