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Literature summary extracted from
- Molecular cloning and functional characterization of cathepsin D from sea cucumber Apostichopus japonicus (2017), Fish Shellfish Immunol., 70, 553-559 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.23.5 | expressed in Escherichia coli BL21(DE3) cells | Apostichopus japonicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.5 | pepstatin A | - |
Apostichopus japonicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.23.5 | lysosome | - |
Apostichopus japonicus | 5764 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.5 | sea cucumber muscle tissue + H2O | Apostichopus japonicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.5 | Apostichopus japonicus | F6LVS9 | sea cucumber | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.23.5 | glutathione Sepharose column chromatography | Apostichopus japonicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.23.5 | body wall | lowest expression | Apostichopus japonicus | - |
| 3.4.23.5 | intestine | highest expression | Apostichopus japonicus | - |
| 3.4.23.5 | muscle | - |
Apostichopus japonicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.5 | sea cucumber muscle tissue + H2O | - |
Apostichopus japonicus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.23.5 | ? | x * 68000, SDS-PAGE | Apostichopus japonicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.5 | CTSD | - |
Apostichopus japonicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.23.5 | Apostichopus japonicus | enzyme expression levels are significantly increased in autolytic tissues | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.23.5 | physiological function | the enzyme contributes to sea cucumber muscle autolysis | Apostichopus japonicus |
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Release 2023.1 (January 2023)
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