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Literature summary extracted from

  • Maize, K.M.; Kurbanov, E.K.; Johnson, R.L.; Amin, E.A.; Finzel, B.C.
    Ligand-induced expansion of the S1 site in the anthrax toxin lethal factor (2015), FEBS Lett., 589, 3836-3841 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.83 expressed in Escherichia coli Rosetta2 pLysS cells Bacillus anthracis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.24.83 hanging drop vapor diffusion method Bacillus anthracis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.83 (2R)-2-[(4-fluoro-3-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
-
 Bacillus anthracis
3.4.24.83 (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
-
 Bacillus anthracis
3.4.24.83 (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)amino]-N-hydroxy-2-(oxan-4-yl)acetamide
-
 Bacillus anthracis
3.4.24.83 (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)[(4-nitrophenyl)methyl]amino]-N-hydroxypropanamide
-
 Bacillus anthracis
3.4.24.83 N-hydroxy-N2-[[3-(methoxymethyl)phenyl]sulfonyl]-N2-(2-methylpropyl)-D-valinamide
-
 Bacillus anthracis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.83 Zn2+ contains zinc Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis P15917
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.83 nickel affinity column chromatography and Superdex S200 gel filtration Bacillus anthracis

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax toxin lethal factor
-
 Bacillus anthracis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.83 0.0001
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)amino]-N-hydroxy-2-(oxan-4-yl)acetamide
3.4.24.83 0.0149
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)[(4-nitrophenyl)methyl]amino]-N-hydroxypropanamide
3.4.24.83 0.09
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
3.4.24.83 0.267
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
3.4.24.83 0.95
-
 pH and temperature not specified in the publication Bacillus anthracis N-hydroxy-N2-[[3-(methoxymethyl)phenyl]sulfonyl]-N2-(2-methylpropyl)-D-valinamide