EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.56 | Somatostatin | enhances the proteolytic processing of a synthetic beta-amyloid-peptide. In addition to being a substrate, somatostatin is also able to bind to two additional exosites, which play different roles according to the size of the substrate and its binding mode to the catalytic cleft of the enzyme. One exosite, which displays high affinity for somatostatin, regulates only the interaction of insulin-degrading-enzyme with larger substrates (such as insulin and beta-amyloid1-40) in a differing fashion according to their various modes of binding to the enzyme. A second exosite, which is involved in the regulation of enzymatic processing by the enzyme of all substrates investigated (including a 10-25 amino acid long amyloid-like peptide, bradykinin and somatostatin itself), probably acts through the alteration of an open-closed equilibrium | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.56 | Homo sapiens | P14735 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.56 | beta-amyloid (Abeta)1-40 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.56 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.56 | insulin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.56 | somatostatin + H2O | somatostatin in addition to being a substrate, is also able to bind to two additional exosites, which play different roles according to the size of the substrate and its binding mode to the catalytic cleft of the enzyme. One exosite, which displays high affinity for somatostatin, regulates only the interaction of insulin-degrading-enzyme with larger substrates (such as insulin and beta-amyloid1-40) in a differing fashion according to their various modes of binding to the enzyme. A second exosite, which is involved in the regulation of enzymatic processing by the enzyme of all substrates investigated (including a 10-25 amino acid long amyloid-like peptide, bradykinin and somatostatin itself), probably acts through the alteration of an open-closed equilibrium | Homo sapiens | ? | - |
? |