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Literature summary extracted from

  • de Sousa, L.R.; Wu, H.; Nebo, L.; Fernandes, J.B.; da Silva, M.F.; Kiefer, W.; Schirmeister, T.; Vieira, P.C.
    Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana (2015), Exp. Parasitol., 156, 42-48 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 3-oxo-urs-12-en-28-oic acid noncompetitive inhibitor Leishmania mexicana
3.4.22.15 agathisflavone noncompetitive inhibitor Leishmania mexicana
3.4.22.15 additional information natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana, overview Leishmania mexicana
3.4.22.15 quercetin
-
 Leishmania mexicana
3.4.22.15 tetrahydrorobustaflavone uncompetitive inhibitor Leishmania mexicana

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Leishmania mexicana E9AMH6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Leishmania mexicana benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.15 cathepsin L-like rCPB2.8
-
 Leishmania mexicana

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.15 25
-
 assay at Leishmania mexicana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.15 6.5
-
 assay at Leishmania mexicana

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.15 additional information
-
 additional information inhibition kinetics Leishmania mexicana
3.4.22.15 0.00014
-
 agathisflavone pH 6.5, 25°C Leishmania mexicana
3.4.22.15 0.00073
-
 tetrahydrorobustaflavone pH 6.5, 25°C Leishmania mexicana
3.4.22.15 0.00126
-
 3-oxo-urs-12-en-28-oic acid pH 6.5, 25°C Leishmania mexicana
3.4.22.15 0.006
-
 quercetin pH 6.5, 25°C Leishmania mexicana

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.15 0.00043
-
 pH 6.5, 25°C Leishmania mexicana agathisflavone
3.4.22.15 0.0022
-
 pH 6.5, 25°C Leishmania mexicana tetrahydrorobustaflavone
3.4.22.15 0.00378
-
 pH 6.5, 25°C Leishmania mexicana 3-oxo-urs-12-en-28-oic acid
3.4.22.15 0.01803
-
 pH 6.5, 25°C Leishmania mexicana quercetin