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Literature summary extracted from

  • Rodrigo, N.; Hocking, S.
    Transient diabetes insipidus in a post-partum woman with pre-eclampsia associated with residual placental vasopressinase activity (2018), Endocrinol. Diabetes Metab. Case Rep., 2018, 18-0052 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.3 additional information Homo sapiens no activity with 1-deamino-8-D-arginine vasopressin ?
-
 ?
3.4.11.3 Vasopressin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.3 Homo sapiens Q9UIQ6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.3 placenta placental trophoblasts. Vasopressinase is proportional to placental weight Homo sapiens
-
3.4.11.3 trophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.3 additional information no activity with 1-deamino-8-D-arginine vasopressin Homo sapiens ?
-
 ?
3.4.11.3 Vasopressin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.3 vasopressinase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.11.3 malfunction diabetes insipidus (DI) is a rare complication of pregnancy occurring in pregnancy, it is associated with excessive vasopressinase activity, secreted by placental trophoblasts, which increases the rate of degradation of anti-diuretic hormone. It is responsive to synthetic desmopressin 1-deamino-8-D-arginine vasopressin as this form is not degraded by placental vasopressinase. Vasopressinase-induced diabetes insipidus is associated with pre-eclampsia Homo sapiens
3.4.11.3 metabolism diabetes insipidus can manifest during pregnancy, induced by increased vasopressinase activity secreted by placental trophoblasts and usually manifests in the third trimester Homo sapiens
3.4.11.3 physiological function placental vasopressinase, expressed in placental trophoblasts, degrades endogenous anti-diuretic hormone (ADH) but not 1-deamino-8-D-arginine vasopressin (dDAVP), the synthetic form with a modified N-terminal, thereby allowing the resolution of symptoms with dDAVP administration Homo sapiens