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Literature summary extracted from

  • Yao, L.; Seaton, S.C.; Ndousse-Fetter, S.; Adhikari, A.A.; DiBenedetto, N.; Mina, A.I.; Banks, A.S.; Bry, L.; Devlin, A.S.
    A selective gut bacterial bile salt hydrolase alters host metabolism (2018), eLife, 7, e37182 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.24 additional information construction of deletion mutant BtDELTABtD2086, that is catalytically inactive. Using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, the levels of the bile acid tauro-beta-muricholic acid in monocolonized gnotobiotic mice are selectively modulated. Bacteroides thetaiotaomicron BSH mutant-colonized mice display altered metabolism, including reduced weight gain and respiratory exchange ratios, as well as transcriptional changes in metabolic, circadian rhythm, and immune pathways in the gut and liver Bacteroides thetaiotaomicron

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.24 glycochenodeoxycholic acid + H2O Bacteroides thetaiotaomicron low activity chenodeoxycholate + glycine
-
 ?
3.5.1.24 glycochenodeoxycholic acid + H2O Bacteroides thetaiotaomicron VPI-5482 low activity chenodeoxycholate + glycine
-
 ?
3.5.1.24 glycodeoxycholic acid + H2O Bacteroides thetaiotaomicron high activity deoxycholate + glycine
-
 ?
3.5.1.24 glycodeoxycholic acid + H2O Bacteroides thetaiotaomicron VPI-5482 high activity deoxycholate + glycine
-
 ?
3.5.1.24 glycolithocholic acid + H2O Bacteroides thetaiotaomicron preferred substrate lithocholate + glycine
-
 ?
3.5.1.24 glycoursodeoxycholic acid + H2O Bacteroides thetaiotaomicron moderate activity ursodeoxycholate + glycine
-
 ?
3.5.1.24 additional information Bacteroides thetaiotaomicron comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview ?
-
 ?
3.5.1.24 additional information Bacteroides thetaiotaomicron VPI-5482 comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview ?
-
 ?
3.5.1.24 tauro-beta-muricholic acid + H2O Bacteroides thetaiotaomicron
-
 beta-muricholate + taurine
-
 ?
3.5.1.24 taurodeoxycholic acid + H2O Bacteroides thetaiotaomicron high activity deoxycholate + taurine
-
 ?
3.5.1.24 taurolithocholic acid + H2O Bacteroides thetaiotaomicron preferred substrate lithocholate + taurine
-
 ?
3.5.1.24 tauroursodeoxycholic acid + H2O Bacteroides thetaiotaomicron moderate activity ursodeoxycholate + taurine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.24 Bacteroides thetaiotaomicron
-
-
-
3.5.1.24 Bacteroides thetaiotaomicron VPI-5482
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.24 glycochenodeoxycholic acid + H2O low activity Bacteroides thetaiotaomicron chenodeoxycholate + glycine
-
 ?
3.5.1.24 glycochenodeoxycholic acid + H2O low activity Bacteroides thetaiotaomicron VPI-5482 chenodeoxycholate + glycine
-
 ?
3.5.1.24 glycodeoxycholic acid + H2O high activity Bacteroides thetaiotaomicron deoxycholate + glycine
-
 ?
3.5.1.24 glycodeoxycholic acid + H2O high activity Bacteroides thetaiotaomicron VPI-5482 deoxycholate + glycine
-
 ?
3.5.1.24 glycolithocholic acid + H2O preferred substrate Bacteroides thetaiotaomicron lithocholate + glycine
-
 ?
3.5.1.24 glycoursodeoxycholic acid + H2O moderate activity Bacteroides thetaiotaomicron ursodeoxycholate + glycine
-
 ?
3.5.1.24 additional information comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview Bacteroides thetaiotaomicron ?
-
 ?
3.5.1.24 additional information selectivity for deconjugating C12 = H but not C12 = OH core primary bile acids. No activity with glycocholic acid and taurocholic acid, taurochenodeoxycholic acid is a poor substrate Bacteroides thetaiotaomicron ?
-
 ?
3.5.1.24 additional information comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview Bacteroides thetaiotaomicron VPI-5482 ?
-
 ?
3.5.1.24 additional information selectivity for deconjugating C12 = H but not C12 = OH core primary bile acids. No activity with glycocholic acid and taurocholic acid, taurochenodeoxycholic acid is a poor substrate Bacteroides thetaiotaomicron VPI-5482 ?
-
 ?
3.5.1.24 tauro-beta-muricholic acid + H2O i.e. TbetaMCA, synthetic fluorogenic substrate of BSH Bacteroides thetaiotaomicron taurine + beta-muricholic acid
-
 ?
3.5.1.24 tauro-beta-muricholic acid + H2O i.e. TbetaMCA, synthetic fluorogenic substrate of BSH Bacteroides thetaiotaomicron VPI-5482 taurine + beta-muricholic acid
-
 ?
3.5.1.24 tauro-beta-muricholic acid + H2O
-
 Bacteroides thetaiotaomicron beta-muricholate + taurine
-
 ?
3.5.1.24 taurodeoxycholic acid + H2O high activity Bacteroides thetaiotaomicron deoxycholate + taurine
-
 ?
3.5.1.24 taurolithocholic acid + H2O preferred substrate Bacteroides thetaiotaomicron lithocholate + taurine
-
 ?
3.5.1.24 tauroursodeoxycholic acid + H2O moderate activity Bacteroides thetaiotaomicron ursodeoxycholate + taurine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.24 bile salt hydrolase
-
 Bacteroides thetaiotaomicron
3.5.1.24 BSH
-
 Bacteroides thetaiotaomicron
3.5.1.24 BT2086
-
 Bacteroides thetaiotaomicron

General Information

EC Number General Information Comment Organism
3.5.1.24 malfunction using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, the levels of the bile acid tauro-beta-muricholic acid in monocolonized gnotobiotic mice are selectively modulated. Bacteroides thetaiotaomicron BSH mutant-colonized mice display altered metabolism, including reduced weight gain and respiratory exchange ratios, as well as transcriptional changes in metabolic, circadian rhythm, and immune pathways in the gut and liver Bacteroides thetaiotaomicron