Literature summary extracted from

Marriott, A.S.; Copeland, N.A.; Cunningham, R.; Wilkinson, M.C.; McLennan, A.G.; Jones, N.J.
Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication (2015), DNA Repair, 33, 90-100 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.6.1.71	Cricetulus griseus	G3I8V7	-	-
3.6.1.71	Homo sapiens	Q7Z2E3	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.6.1.71	CHO-AA8 cell	-	Cricetulus griseus	-
3.6.1.71	CHO-EM9 cell	-	Cricetulus griseus	-
3.6.1.71	FD105 cell	FD105-M20 cell	Homo sapiens	-
3.6.1.71	FD105 cell	FD105-M21 cell	Homo sapiens	-
3.6.1.71	HeLa cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.6.1.71	I79_019989	-	Cricetulus griseus

General Information

EC Number	General Information	Comment	Organism
3.6.1.71	physiological function	FD105 cells, lacking aprataxin, show a 5.7-fold increase in diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) level	Homo sapiens
3.6.1.71	physiological function	knockdown of aprataxin expression in EM-9 cells leads to an 8fold increase in Ap4A level to 31.4 pmol/106 cells. APTX knockdown greatly enhances the mitomycin C-induced Ap4A increase in AA-8 cells from 3.9 to 10.6 pmol/106 cells	Cricetulus griseus

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Release 2023.1 (January 2023)