Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lin, H.; Zhu, X.; Chen, G.; Song, L.; Gao, L.; Khand, A.; Chen, Y.; Lin, G.; Tao, Q.
    KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis (2017), Development, 144, 3674-3685 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.65 a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Xenopus laevis overall reaction a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.65 a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Xenopus laevis
-
 a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Xenopus laevis
-
 a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 additional information Xenopus laevis the enzyme KDM3A is associated with Neurog2 protein, but not Ascl1 protein. Neurog2 recruits the enzyme to demethylate [histone H3]-N6,N6-dimethyl-L-lysine9 at the neurod1 promoter ?
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Xenopus laevis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.65 embryo
-
 Xenopus laevis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Xenopus laevis a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.65 a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Xenopus laevis a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Xenopus laevis a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 additional information the enzyme KDM3A is associated with Neurog2 protein, but not Ascl1 protein. Neurog2 recruits the enzyme to demethylate [histone H3]-N6,N6-dimethyl-L-lysine9 at the neurod1 promoter Xenopus laevis ?
-
-

Synonyms

EC Number Synonyms Comment Organism
1.14.11.65 histone H3 lysine 9 demethylase
-
 Xenopus laevis
1.14.11.65 Kdm3a
-
 Xenopus laevis

General Information

EC Number General Information Comment Organism
1.14.11.65 malfunction enzyme depletion results in defective primary neurogenesis in early Xenopus embryos Xenopus laevis
1.14.11.65 physiological function KDM3A facilitates the Xenopus Neurog2 (regulator of neuronal fate specification and differentiation) chromatin accessibility during neuronal transcription. KDM3A is not required for the transition of naive ectoderm to neural progenitor cells but is essential for primary neuron formation. Neurog2 promotes the removal of the repressive H3K9me2 marks and addition of active histone marks, including H3K27ac and H3K4me3, at the NeuroD1 and Tubb2b promoters, the activity depends on the presence of KDM3A Xenopus laevis
1.14.11.65 physiological function the enzyme facilitates the Xenopus Neurog2 chromatin accessibility during neuronal transcription. The enzyme is not required for the transition of naive ectoderm to neural progenitor cells but is essential for primary neuron formation Xenopus laevis