EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.46 | 15,16-dihydrotanshinone | - |
Homo sapiens | |
3.4.23.46 | 2-amino-3-[(1R)-1-cyclohexyl-2-[(cyclohexylcarbonyl)amino]ethyl]-6-phenoxyquinazolin-3-ium | - |
Homo sapiens | |
3.4.23.46 | 4',5,7-trimethoxyflavone | - |
Homo sapiens | |
3.4.23.46 | caffeic acid | - |
Homo sapiens | |
3.4.23.46 | cryptotanshinone | - |
Homo sapiens | |
3.4.23.46 | dehydrodanshenol A | - |
Homo sapiens | |
3.4.23.46 | deoxyneocryptotanshinone | mixed-type inhibition | Homo sapiens | |
3.4.23.46 | ferruginol | - |
Homo sapiens | |
3.4.23.46 | grandifolia F | - |
Homo sapiens | |
3.4.23.46 | magnesium lithospermate | - |
Homo sapiens | |
3.4.23.46 | methyl tanshinonate | - |
Homo sapiens | |
3.4.23.46 | quercetin | - |
Homo sapiens | |
3.4.23.46 | rosmarinic acid | - |
Homo sapiens | |
3.4.23.46 | salvianolic acid A | competitive type inhibition | Homo sapiens | |
3.4.23.46 | salvianolic acid B | - |
Homo sapiens | |
3.4.23.46 | salvianolic acid C | mixed-type inhibition | Homo sapiens | |
3.4.23.46 | tanshinol B | - |
Homo sapiens | |
3.4.23.46 | tanshinonal | - |
Homo sapiens | |
3.4.23.46 | tanshinone I | - |
Homo sapiens | |
3.4.23.46 | tanshinone IIA | - |
Homo sapiens | |
3.4.23.46 | tanshinone IIB | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.46 | amyloid-beta precursor protein + H2O | Homo sapiens | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.46 | Homo sapiens | P56817 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.46 | amyloid-beta precursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.23.46 | Rh-EVNLDAEFK-quencher + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.23.46 | BACE1 | - |
Homo sapiens |
3.4.23.46 | beta-site amyloid precursor protein enzyme 1 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.23.46 | 0.00918 | - |
at pH 4.5 and 23°C | Homo sapiens | salvianolic acid C | |
3.4.23.46 | 0.01049 | - |
at pH 4.5 and 23°C | Homo sapiens | quercetin | |
3.4.23.46 | 0.01153 | - |
at pH 4.5 and 23°C | Homo sapiens | deoxyneocryptotanshinone | |
3.4.23.46 | 0.01301 | - |
at pH 4.5 and 23°C | Homo sapiens | salvianolic acid A | |
3.4.23.46 | 0.02846 | - |
at pH 4.5 and 23°C | Homo sapiens | tanshinone I | |
3.4.23.46 | 0.02977 | - |
at pH 4.5 and 23°C | Homo sapiens | rosmarinic acid | |
3.4.23.46 | 0.03034 | - |
at pH 4.5 and 23°C | Homo sapiens | dehydrodanshenol A | |
3.4.23.46 | 0.03035 | - |
at pH 4.5 and 23°C | Homo sapiens | magnesium lithospermate | |
3.4.23.46 | 0.03402 | - |
at pH 4.5 and 23°C | Homo sapiens | tanshinonal | |
3.4.23.46 | 0.0356 | - |
at pH 4.5 and 23°C | Homo sapiens | methyl tanshinonate | |
3.4.23.46 | 0.03995 | - |
at pH 4.5 and 23°C | Homo sapiens | cryptotanshinone | |
3.4.23.46 | 0.04863 | - |
at pH 4.5 and 23°C | Homo sapiens | 15,16-dihydrotanshinone | |
3.4.23.46 | 0.09186 | - |
at pH 4.5 and 23°C | Homo sapiens | tanshinone IIA | |
3.4.23.46 | 0.09822 | - |
at pH 4.5 and 23°C | Homo sapiens | tanshinol B | |
3.4.23.46 | 0.10306 | - |
at pH 4.5 and 23°C | Homo sapiens | grandifolia F | |
3.4.23.46 | 0.2 | - |
at pH 4.5 and 23°C | Homo sapiens | caffeic acid | |
3.4.23.46 | 0.2 | - |
at pH 4.5 and 23°C | Homo sapiens | ferruginol | |
3.4.23.46 | 0.2 | - |
at pH 4.5 and 23°C | Homo sapiens | tanshinone IIB |