Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yu, T.; Paudel, P.; Seong, S.H.; Kim, J.A.; Jung, H.A.; Choi, J.S.
    Computational insights into beta-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations (2018), Comput. Biol. Chem., 74, 273-285 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.46 15,16-dihydrotanshinone
-
Homo sapiens
3.4.23.46 2-amino-3-[(1R)-1-cyclohexyl-2-[(cyclohexylcarbonyl)amino]ethyl]-6-phenoxyquinazolin-3-ium
-
Homo sapiens
3.4.23.46 4',5,7-trimethoxyflavone
-
Homo sapiens
3.4.23.46 caffeic acid
-
Homo sapiens
3.4.23.46 cryptotanshinone
-
Homo sapiens
3.4.23.46 dehydrodanshenol A
-
Homo sapiens
3.4.23.46 deoxyneocryptotanshinone mixed-type inhibition Homo sapiens
3.4.23.46 ferruginol
-
Homo sapiens
3.4.23.46 grandifolia F
-
Homo sapiens
3.4.23.46 magnesium lithospermate
-
Homo sapiens
3.4.23.46 methyl tanshinonate
-
Homo sapiens
3.4.23.46 quercetin
-
Homo sapiens
3.4.23.46 rosmarinic acid
-
Homo sapiens
3.4.23.46 salvianolic acid A competitive type inhibition Homo sapiens
3.4.23.46 salvianolic acid B
-
Homo sapiens
3.4.23.46 salvianolic acid C mixed-type inhibition Homo sapiens
3.4.23.46 tanshinol B
-
Homo sapiens
3.4.23.46 tanshinonal
-
Homo sapiens
3.4.23.46 tanshinone I
-
Homo sapiens
3.4.23.46 tanshinone IIA
-
Homo sapiens
3.4.23.46 tanshinone IIB
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.46 amyloid-beta precursor protein + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.46 Homo sapiens P56817
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.46 amyloid-beta precursor protein + H2O
-
Homo sapiens ?
-
?
3.4.23.46 Rh-EVNLDAEFK-quencher + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.46 BACE1
-
Homo sapiens
3.4.23.46 beta-site amyloid precursor protein enzyme 1
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.23.46 0.00918
-
at pH 4.5 and 23°C Homo sapiens salvianolic acid C
3.4.23.46 0.01049
-
at pH 4.5 and 23°C Homo sapiens quercetin
3.4.23.46 0.01153
-
at pH 4.5 and 23°C Homo sapiens deoxyneocryptotanshinone
3.4.23.46 0.01301
-
at pH 4.5 and 23°C Homo sapiens salvianolic acid A
3.4.23.46 0.02846
-
at pH 4.5 and 23°C Homo sapiens tanshinone I
3.4.23.46 0.02977
-
at pH 4.5 and 23°C Homo sapiens rosmarinic acid
3.4.23.46 0.03034
-
at pH 4.5 and 23°C Homo sapiens dehydrodanshenol A
3.4.23.46 0.03035
-
at pH 4.5 and 23°C Homo sapiens magnesium lithospermate
3.4.23.46 0.03402
-
at pH 4.5 and 23°C Homo sapiens tanshinonal
3.4.23.46 0.0356
-
at pH 4.5 and 23°C Homo sapiens methyl tanshinonate
3.4.23.46 0.03995
-
at pH 4.5 and 23°C Homo sapiens cryptotanshinone
3.4.23.46 0.04863
-
at pH 4.5 and 23°C Homo sapiens 15,16-dihydrotanshinone
3.4.23.46 0.09186
-
at pH 4.5 and 23°C Homo sapiens tanshinone IIA
3.4.23.46 0.09822
-
at pH 4.5 and 23°C Homo sapiens tanshinol B
3.4.23.46 0.10306
-
at pH 4.5 and 23°C Homo sapiens grandifolia F
3.4.23.46 0.2
-
at pH 4.5 and 23°C Homo sapiens caffeic acid
3.4.23.46 0.2
-
at pH 4.5 and 23°C Homo sapiens ferruginol
3.4.23.46 0.2
-
at pH 4.5 and 23°C Homo sapiens tanshinone IIB