EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | angiotensin I + H2O | Homo sapiens | - |
angiotensin II + L-His-L-Leu | - |
? | |
3.4.17.23 | angiotensin I + H2O | Homo sapiens | - |
DRVYIHPFH + L-Leu | - |
? | |
3.4.17.23 | angiotensin II + H2O | Homo sapiens | - |
DRVYIHP + L-Phe | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.15.1 | Homo sapiens | P12821 | - |
- |
3.4.17.23 | Homo sapiens | Q9BYF1 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.15.1 | blood vessel | - |
Homo sapiens | - |
3.4.15.1 | monocyte | classical, CD14++CD16- cells | Homo sapiens | - |
3.4.15.1 | additional information | highest relative level of ACE1 mRNA expression is observed in CD14++CD16- (classical) monocytes. In peripheral blood mononuclear cells (PBMC), monocytes and classical monocytes, ACE1 protein expression is stronger compared to other monocyte subpopulations. ACE1 expression is slightly more diverse than ACE2 (EC 3.4.17.23) levels, imune cell expression analysis | Homo sapiens | - |
3.4.15.1 | peripheral blood mononuclear cell | PBMC | Homo sapiens | - |
3.4.17.23 | blood vessel | - |
Homo sapiens | - |
3.4.17.23 | monocyte | classical, CD14++CD16- cells | Homo sapiens | - |
3.4.17.23 | additional information | highest relative level of ACE2 mRNA expression is observed in CD14++CD16- (classical) monocytes. In peripheral blood mononuclear cells (PBMC), monocytes and classical monocytes, ACE2 protein expression is stronger compared to other monocyte subpopulations. ACE1 (EC 3.4.15.1) expression is slightly more diverse than ACE2 levels, immune cell expression analysis | Homo sapiens | - |
3.4.17.23 | peripheral blood mononuclear cell | PBMC | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | angiotensin I + H2O | - |
Homo sapiens | angiotensin II + L-His-L-Leu | - |
? | |
3.4.17.23 | angiotensin I + H2O | - |
Homo sapiens | DRVYIHPFH + L-Leu | - |
? | |
3.4.17.23 | angiotensin II + H2O | - |
Homo sapiens | DRVYIHP + L-Phe | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.15.1 | ACEI | - |
Homo sapiens |
3.4.15.1 | angiotensin-converting enzyme type 1 | - |
Homo sapiens |
3.4.17.23 | ACEII | - |
Homo sapiens |
3.4.17.23 | angiotensin-converting enzyme type 2 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.15.1 | metabolism | the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview | Homo sapiens |
3.4.15.1 | physiological function | the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview. Because of intensive local formation, the actions of nonclassical angiotensins could be especially important in the paracrine regulation of tissue physiology. RAAS may play a role in the regulation of blood pressure not only in a systemic endocrine manner, but also by local actions of various angiotensins (renin-angiotensin system, RAS) on vessel wall homeostasis | Homo sapiens |
3.4.17.23 | metabolism | the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview | Homo sapiens |
3.4.17.23 | physiological function | the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview | Homo sapiens |