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Literature summary extracted from

  • Papait, R.; Serio, S.; Pagiatakis, C.; Rusconi, F.; Carullo, P.; Mazzola, M.; Salvarani, N.; Miragoli, M.; Condorelli, G.
    Histone methyltransferase G9a is required for cardiomyocyte homeostasis and hypertrophy (2017), Circulation, 136, 1233-1246 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.355 BIX-01294 specific inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Mus musculus Q9Z148
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 cardiomyocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 EHMT2
-
 Mus musculus
2.1.1.355 G9a
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.355 physiological function the enzyme is required for cardiomyocyte homeostasis in the adult heart by mediating the repression of key genes regulating cardiomyocyte function via dimethylation of H3 lysine 9 and interaction with enhancer of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, and MEF2C-dependent gene expression by forming a complex with this transcription factor. The enzyme-MEF2C complex is required for the maintenance of heterochromatin needed for the silencing of developmental genes in the adult heart. The enzyme promotes cardiac hypertrophy by repressing antihypertrophic genes Mus musculus