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Literature summary extracted from

  • Traitcheva, N.; Jenke-Kodama, H.; He, J.; Dittmann, E.; Hertweck, C.
    Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways An evolutionary perspective (2007), ChemBioChem, 8, 1841-1849 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.289 Streptomyces thioluteus Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
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2.3.1.289 Streptomyces thioluteus HKI-227 Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
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2.3.1.290 Streptomyces orinoci B4ER92 and B4ER95 and B4ER96 and B4ER97 B4ER92 i.e. subunit NorA, B4ER95 i.e. subunit NorA', B4ER96 i.e. subunit NorB, B4ER97 i.e. subunit NorC
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.290 4-nitrobenzoyl-CoA + malonyl-CoA + 6 (S)-methylmalonyl-CoA + 6 NADPH + 4 H+
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 Streptomyces orinoci demethyldeoxyspectinabilin + 7 CO2 + 8 CoA + 6 NADP+ + 5 H2O
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General Information

EC Number General Information Comment Organism
2.3.1.289 physiological function comparison of Stretomyces thiolueus aureothin and Streptomyces orinoci neoaureothin gene clusters and enzymes. In both cases individual polyketide synthase modules are used in an iterative fashion Streptomyces thioluteus
2.3.1.290 physiological function enzyme generates the backbone of the antibiotic spectinabilin. It is composed of 6 modules and is encoded by four genes. The enzyme extends 4-nitrobenzoyl-CoA by 6 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by norA) is used twice in an iterative fashion, so that the seven Claisen condensation reactions are catalysed by only six modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric). Comparison of Stretomyces thiolueus aureothin and Streptomyces orinoci neoaureothin gene clusters and enzymes Streptomyces orinoci