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Literature summary extracted from

  • Morse, J.; Lalonde, T.; Xu, S.; Liu, W.
    Learning from the Past Possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV (2020), ChemBioChem, 21, 730-738 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 aurintricarboxylic acid
-
 Severe acute respiratory syndrome-related coronavirus
2.7.7.48 additional information the high sequence conservation between SARS-CoV RNA-dependent RNA polymerase (RdRp) and SARS-CoV-2 RNA polymerase makes it very likely that any potent agents developed for the SARS-CoV RdRp will exhibit equal potency and efficacy on the SARS-CoV-2 enzyme Severe acute respiratory syndrome coronavirus 2
2.7.7.48 additional information the high sequence conservation between SARS-CoV RNA-dependent RNA polymerase (RdRp) and SARS-CoV-2 RNA polymerase makes it very likely that any potent agents developed for the SARS-CoV RdRp will exhibit equal potency and efficacy on the SARS-CoV-2 enzyme Severe acute respiratory syndrome-related coronavirus
2.7.7.48 remdesivir
-
 Severe acute respiratory syndrome-related coronavirus
2.7.7.48 ribavirin
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 (2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 (4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide
-
 Severe acute respiratory syndrome-related coronavirus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Severe acute respiratory syndrome coronavirus 2 MN908947 i.e. SARS-CoV-2
-
2.7.7.48 Severe acute respiratory syndrome-related coronavirus P0C6X7 human, i.e. SARS-CoV
-
3.4.22.69 Severe acute respiratory syndrome-related coronavirus P0C6X7 human, i.e. SARS-CoV
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
-
 Severe acute respiratory syndrome-related coronavirus
2.7.7.48 RDRP
-
 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 RNA-dependent RNA polymerase
-
 Severe acute respiratory syndrome coronavirus 2
3.4.22.69 3C-like peptidase
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 3cLpro
-
 Severe acute respiratory syndrome-related coronavirus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.69 0.0002
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide
3.4.22.69 0.00104
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus 5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione
3.4.22.69 0.00118
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus 5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione
3.4.22.69 0.0071
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus (2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
3.4.22.69 0.0362
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus (4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one

General Information

EC Number General Information Comment Organism
2.7.7.48 drug target the high sequence conservation between SARS-CoV RNA-dependent RNA polymerase (RdRp) and SARS-CoV-2 RNA polymerase makes it very likely that any potent agents developed for the SARS-CoV RdRp will exhibit equal potency and efficacy on the SARS-CoV-2 enzyme Severe acute respiratory syndrome-related coronavirus
2.7.7.48 drug target the high sequence conservation between SARS-CoV RNA-dependent RNA polymerase (RdRp) and SARS-CoV-2 RNA polymerase makes it very likely that any potent agents developed for the SARS-CoV RdRp will exhibit equal potency and efficacy on the SARS-CoV-2 enzyme Severe acute respiratory syndrome coronavirus 2
3.4.22.69 physiological function the protease 3CLpro processes the polypeptide translation product from the genomic RNA into the structural and nonstructural protein components vital for the replication and packaging of a new generation of viruses Severe acute respiratory syndrome-related coronavirus