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Literature summary extracted from

  • Pedre, B.; van Bergen, L.A.; Pallo, A.; Rosado, L.A.; Dufe, V.T.; Molle, I.V.; Wahni, K.; Erdogan, H.; Alonso, M.; Proft, F.D.; Messens, J.
    The active site architecture in peroxiredoxins a case study on Mycobacterium tuberculosis AhpE (2016), Chem. Commun. (Camb.), 52, 10293-10296 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.11.1.29 X-ray crystal structures of the MtAhpE mutants R116A and F37H at high resolution (1.74 A for R116A and 1.38 A for F37H). It is not possible to obtain the crystal structure of the T42V variant Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.29 F37H no apparent impairment in H2O2 reduction Mycobacterium tuberculosis
1.11.1.29 R116A impairment in H2O2 reduction Mycobacterium tuberculosis
1.11.1.29 T42V impairment in H2O2 reduction Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.29 Mycobacterium tuberculosis P9WIE3
-
-
1.11.1.29 Mycobacterium tuberculosis ATCC 25618 P9WIE3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.29 mycoredoxin + H2O2
-
 Mycobacterium tuberculosis mycoredoxin disulfide + H2O
-
 ?
1.11.1.29 mycoredoxin + H2O2
-
 Mycobacterium tuberculosis ATCC 25618 mycoredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.29 AhpE
-
 Mycobacterium tuberculosis
1.11.1.29 alkyl hydroperoxide reductase E
-
 Mycobacterium tuberculosis