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Literature summary extracted from

  • Ogiwara, K.; Takahashi, T.
    Nuclear progestin receptor phosphorylation by Cdk9 is required for the expression of Mmp15, a protease indispensable for ovulation in Medaka (2019), Cells, 8, 215 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B5 gene mmp15, reverse transcription and real-time PCR expression analysis Oryzias latipes

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B5 extracellular matrix
-
 Oryzias latipes 31012
-
3.4.24.B5 membrane
-
 Oryzias latipes 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B5 Zn2+ a zinc-dependent endopeptidase Oryzias latipes

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B5 Oryzias latipes H2MKS4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B5 follicle layer of the ovarian follicles Oryzias latipes
-
3.4.24.B5 additional information MMP-15 enzyme expression analysis, overview Oryzias latipes
-
3.4.24.B5 ovarian follicle
-
 Oryzias latipes
-
3.4.24.B5 ovary
-
 Oryzias latipes
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B5 membrane type 2-Mmp
-
 Oryzias latipes
3.4.24.B5 MMP15
-
 Oryzias latipes
3.4.24.B5 Mt2-mmp/Mmp15
-
 Oryzias latipes

Expression

EC Number Organism Comment Expression
3.4.24.B5 Oryzias latipes inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. Roscovitine treatment of follicles inhibits Pgr binding to the mmp15 promoter region down
3.4.24.B5 Oryzias latipes after phosphorylation (by CDK9 and cyclin 1), Pgr becomes a functional transcription factor for mmp15 gene expression additional information
3.4.24.B5 Oryzias latipes Mmp15 is an luteinizing hormone (LH)-inducible enzyme up

General Information

EC Number General Information Comment Organism
3.4.24.B5 malfunction inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. In follicles treated with the inhibitors, the formation of the phosphorylated nuclear progestin receptor (Pgr) is inhibited. Roscovitine treatment causes a reduction in the binding of Pgr to the promoter region of gene mmp15 Oryzias latipes
3.4.24.B5 physiological function nuclear progestin receptor phosphorylation by Cdk9 is required for the expression of Mmp15, a protease indispensable for ovulation in Medaka. The enzyme MMP-15 is involved in follicle layer extracellular matrix hydrolysis Oryzias latipes