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Literature summary extracted from

  • Baduva, K.; Buechter, L.; Kreyenkamp, K.; Westphal, L.; Wilker, B.; Kohnen, M.; Schuchman, E.H.; Edwards, M.J.; Becker, K.A.; Gulbins, E.; Carpinteiro, A.
    Signalling effects induced by acid ceramidase in human epithelial or leukemic cell lines (2019), Cell. Physiol. Biochem., 52, 1092-1102 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Homo sapiens
-
 sphingosine + a fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Homo sapiens Q13510
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 Chang cell a conjunctiva epithelial cell line Homo sapiens
-
3.5.1.23 epithelial cell
-
 Homo sapiens
-
3.5.1.23 JURKAT cell
-
 Homo sapiens
-
3.5.1.23 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 ceramide + H2O
-
 Homo sapiens sphingosine + a fatty acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.23 acid ceramidase
-
 Homo sapiens
3.5.1.23 ASAH1
-
 Homo sapiens
3.5.1.23 N-acylsphingosine aminohydrolase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.1.23 additional information treatment of cultured epithelial Chang cells or leukemic T-lymphocytes (Jurkat cells) with purified acid ceramidase results in a dose dependent activation of AKT, p38-kinase and p70S6-kinase, while tyrosine phosphorylation of intracellular proteins remains largely unchanged, determination of intracellular signalling events, proliferation and cell survival, overview. Acid ceramidase treatment does not change expression of tight junction proteins such as ZO-1, ZO-2 and occludin. Cellular viability and proliferation are not affected by acid ceramidase treatment Homo sapiens
3.5.1.23 physiological function signalling effects induced by acid ceramidase in human epithelial or leukemic cell lines Homo sapiens