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Literature summary extracted from

  • Qiu, J.; Shi, G.; Jia, Y.; Li, J.; Wu, M.; Li, J.; Dong, S.; Wong, J.
    The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation (2010), Cell Res., 20, 908-18 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.65 F279S mutation identified in X-linked mental retardation patients, mutant is defective in enzymatic activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Homo sapiens Q9UPP1
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
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 Homo sapiens a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
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 ?
1.14.11.65 a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
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 Homo sapiens a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 additional information PHF8 exhibits both H3K4 and H3K9 demethylase activity in cells, but recombinant PHF8 exhibits only H3K9me2/1 demethylase activity in vitro Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.65 PHF8
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 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.65 physiological function PHF8 binds specifically to H3K4me3/2 peptides via an N-terminal PHD finger domain. Knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs retinoic acid-induced neuronal differentiation, whereas overexpression of PHF8 drives P19 cells toward neuronal differentiation. PHF8 interacts with retinoic acid receptor alpha and functions as a coactivator Homo sapiens