Literature summary extracted from

Zhu, Z.; Wang, Y.; Li, X.; Wang, Y.; Xu, L.; Wang, X.; Sun, T.; Dong, X.; Chen, L.; Mao, H.; Yu, Y.; Li, J.; Chen, P.; Chen, C.
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis (2010), Cell Res., 20, 794-801 .

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.14.11.65	H247A	complete loss of activity	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.11.65	nucleolus	PHF8 colocalizes with B23 and fibrillarin	Homo sapiens	5730	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.11.65	Homo sapiens	Q9UPP1	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.11.65	a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2	-	Homo sapiens	a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.11.65	PHF8	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
1.14.11.65	physiological function	PHF8 binds to the promoter region of the rDNA gene. Knockdown of PHF8 reduces the expression of rRNA, and overexpression results in upregulation of rRNA transcript. Concomitantly, H3K9me2 levels are elevated in the promoter region of the rDNA gene in PHF8 knockdown cells and significantly reduced upon overexpression of PHF8	Homo sapiens

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Release 2023.1 (January 2023)