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Literature summary extracted from

  • Zhang, Y.; Xue, W.; Zhang, W.; Yuan, Y.; Zhu, X.; Wang, Q.; Wei, Y.; Yang, D.; Yang, C.; Chen, Y.; Sun, Y.; Wang, S.; Huang, K.; Zheng, L.
    Histone methyltransferase G9a protects against acute liver injury through GSTP1 (2019), Cell Death Differ., 27, 1243-1258 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus
-
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Mus musculus
-
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Mus musculus
-
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Mus musculus Q9Z148
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 liver
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.355 ? x * 130000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 G9a
-
Mus musculus
2.1.1.355 histone methyltransferase
-
Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.355 malfunction inhibiting the methyltransferase activity of the enzyme aggravates lipopolysaccharide-induced liver damage Mus musculus