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Literature summary extracted from

  • Abfalter, C.; Schubert, M.; Götz, C.; Schmidt, T.; Posselt, G.; Wessler, S.
    HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens (2016), Cell Commun. Signal., 14, 30.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B50
-
 Escherichia coli O127:H6
3.4.21.B50
-
 Proteus mirabilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B50 E-cadherin + H2O Escherichia coli O127:H6 infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis ?
-
 ?
3.4.21.B50 E-cadherin + H2O Proteus mirabilis infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis ?
-
 ?
3.4.21.B50 E-cadherin + H2O Proteus mirabilis HI4320 infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis ?
-
 ?
3.4.21.B50 E-cadherin + H2O Escherichia coli O127:H6 E2348/69 infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B50 Escherichia coli O127:H6 B7UJW6
-
-
3.4.21.B50 Escherichia coli O127:H6 E2348/69 B7UJW6
-
-
3.4.21.B50 Proteus mirabilis B4EXL6
-
-
3.4.21.B50 Proteus mirabilis HI4320 B4EXL6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B50
-
 Escherichia coli O127:H6
3.4.21.B50
-
 Proteus mirabilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B50 E-cadherin + H2O infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis Escherichia coli O127:H6 ?
-
 ?
3.4.21.B50 E-cadherin + H2O infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis Proteus mirabilis ?
-
 ?
3.4.21.B50 E-cadherin + H2O
-
 Escherichia coli O127:H6 ?
-
 ?
3.4.21.B50 E-cadherin + H2O
-
 Proteus mirabilis ?
-
 ?
3.4.21.B50 E-cadherin + H2O infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis Proteus mirabilis HI4320 ?
-
 ?
3.4.21.B50 E-cadherin + H2O
-
 Proteus mirabilis HI4320 ?
-
 ?
3.4.21.B50 E-cadherin + H2O infection of epithelial cells results in a strong E-cadherin ectodomain shedding as reflected by the loss of full length E-cadherin in whole cell lysates and formation of the soluble 90 kDa extracellular domain of E-cadherin in the supernatants of infected cells. E-cadherin cleavage is an important step in bacterial pathogenesis Escherichia coli O127:H6 E2348/69 ?
-
 ?
3.4.21.B50 E-cadherin + H2O
-
 Escherichia coli O127:H6 E2348/69 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B50 DegQ
-
 Escherichia coli O127:H6
3.4.21.B50 DegQ
-
 Proteus mirabilis

General Information

EC Number General Information Comment Organism
3.4.21.B50 physiological function E-cadherin cleavage is an important step in bacterial pathogenesis Escherichia coli O127:H6
3.4.21.B50 physiological function E-cadherin cleavage is an important step in bacterial pathogenesis Proteus mirabilis