EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.11.69 | medicine | KDM4A is both amplified and deleted across many disparate cancer types, and KDM4A expression correlates with copy number in these samples. 46% of ovarian cancer cells display KDM4A amplification, which correlates with expression | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.11.66 | gene KDM4A, transient recombinant overexpression in RPE cells | Homo sapiens |
1.14.11.69 | gene KDM4A, transient recombinant overexpression in RPE cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.11.66 | nucleus | - |
Homo sapiens | 5634 | - |
1.14.11.69 | nucleus | - |
Homo sapiens | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.66 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.66 | Homo sapiens | O75164 | - |
- |
1.14.11.69 | Homo sapiens | O75164 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.11.66 | carcinoma cell | KDM4A is amplified and overexpressed in cancer cells of several tumor types | Homo sapiens | - |
1.14.11.69 | carcinoma cell | KDM4A is amplified and overexpressed in cancer cells of several tumor types | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.66 | additional information | bifunctional H3K9/36me3 lysine demethylase KDM4A/JMJD2A acting on Lys 9 and Lys36 of histone 3 | Homo sapiens | ? | - |
? | |
1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.66 | [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.69 | additional information | bifunctional H3K9/36me3 lysine demethylase KDM4A/JMJD2A acting on Lys 9 and Lys36 of histone 3 | Homo sapiens | ? | - |
? | |
1.14.11.69 | [histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.66 | H3K9/36me3 lysine demethylase | - |
Homo sapiens |
1.14.11.66 | KDM4A lysine demethylase | - |
Homo sapiens |
1.14.11.66 | KDM4A/JMJD2A | - |
Homo sapiens |
1.14.11.66 | More | see also EC 1.14.11.69 | Homo sapiens |
1.14.11.69 | H3K9/36me3 lysine demethylase | - |
Homo sapiens |
1.14.11.69 | KDM4A lysine demethylase | - |
Homo sapiens |
1.14.11.69 | KDM4A/JMJD2A | - |
Homo sapiens |
1.14.11.69 | More | see also EC 1.14.11.66 | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.11.66 | evolution | KDM4A belongs to the KDM4 family | Homo sapiens |
1.14.11.66 | malfunction | KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q21, and Xq13.1 without global chromosome instability, KDM4A-amplified tumors have increased copy gains for these same regions. 1q12h copy gain occurs within a single cell cycle, requires S phase, and is not stable but is regenerated each cell division. Sites with increased copy number are rereplicated and have increased KDM4A, MCM, and DNA polymerase occupancy. Suv39h1/KMT1A or HP1g overexpression suppresses the copy gain, whereas H3K9/K36 methylation interference promotes gain. Overexpression of a chromatin modifier results in site-specific copy gains | Homo sapiens |
1.14.11.66 | physiological function | H3K9me3 demethylase KDM4A/JMJD2A is able to increase accessibility and alter the replication timing at specific heterochromatic regions. KDM4A overexpression promotes copy gain of 1q12, 1q21, and Xq13.1 in cancer cells and results in site-specific copy gain of regions amplified in human tumors. These copy gains are not stably inherited but are generated transiently in each subsequent S phase and cleared by late G2. KDM4A is the only KDM4 family member that generated the gains in a catalytically dependent manner, copy gains are antagonized by coexpression of Suv39h1/KMT1A or HP1gamma, and promoted by H3K9 or H3K36 methylation interference. KDM4A associates with replication machinery and promotes rereplication of 1q12. KDM4A overexpression promotes chromatin state changes and recruitment of replication machinery. KDM4A-dependent 1q12h copy gain requires catalytic activity and Tudor domains, the KDM4A catalytic domain alone is insufficient to generate 1q12h gain | Homo sapiens |
1.14.11.69 | evolution | KDM4A belongs to the KDM4 family | Homo sapiens |
1.14.11.69 | malfunction | KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q21, and Xq13.1 without global chromosome instability, KDM4A-amplified tumors have increased copy gains for these same regions. 1q12h copy gain occurs within a single cell cycle, requires S phase, and is not stable but is regenerated each cell division. Sites with increased copy number are rereplicated and have increased KDM4A, MCM, and DNA polymerase occupancy. Suv39h1/KMT1A or HP1gamma overexpression suppresses the copy gain, whereas H3K9/K36 methylation interference promotes gain. Overexpression of a chromatin modifier results in site-specific copy gains | Homo sapiens |
1.14.11.69 | physiological function | H3K9me3 demethylase KDM4A/JMJD2A is able to increase accessibility and alter the replication timing at specific heterochromatic regions. KDM4A overexpression promotes copy gain of 1q12, 1q21, and Xq13.1 in cancer cells and results in site-specific copy gain of regions amplified in human tumors. These copy gains are not stably inherited but are generated transiently in each subsequent S phase and cleared by late G2. KDM4A is the only KDM4 family member that generated the gains in a catalytically dependent manner, copy gains are antagonized by coexpression of Suv39h1/KMT1A or HP1gamma, and promoted by H3K9 or H3K36 methylation interference. KDM4A associates with replication machinery and promotes rereplication of 1q12. KDM4A overexpression promotes chromatin state changes and recruitment of replication machinery. KDM4A-dependent 1q12h copy gain requires catalytic activity and Tudor domains, the KDM4A catalytic domain alone is insufficient to generate 1q12h gain | Homo sapiens |
1.14.11.69 | physiological function | KDM4A overexpression promotes chromatin state changes and recruitment of replication machinery and leads to localized copy gain of cytogenetic bands 1q12, 1q21, and Xq13.1 without global chromosome instability. KDM4A-amplified tumors have increased copy gains for these same regions. 1q12h copy gain occurs within a single cell cycle, requires S phase and is not stable but regenerated each cell division. Sites with increased copy number are rereplicated and have increased KDM4A, MCM and DNA polymerase occupancy. Suv39h1/KMT1A or HP1gamma overexpression suppresses the copy gain, while H3K9/K36 methylation interference promotes gain | Homo sapiens |