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Literature summary extracted from

  • Vincent, B.
    Regulation of the alpha-secretase ADAM10 at transcriptional, translational and post-translational levels (2016), Brain Res. Bull., 126, 154-169 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.81 5-hydroxytryptamine receptor
-
 Homo sapiens
3.4.24.81 acetyl-L-carnitine
-
 Homo sapiens
3.4.24.81 ADAM15
-
 Homo sapiens
3.4.24.81 ADAM9
-
 Homo sapiens
3.4.24.81 bombesin receptor
-
 Homo sapiens
3.4.24.81 cryptotanshinone
-
 Homo sapiens
3.4.24.81 Deprenyl
-
 Homo sapiens
3.4.24.81 donezipil
-
 Homo sapiens
3.4.24.81 epigallocatechin-3-gallate
-
 Homo sapiens
3.4.24.81 FLZ synthetic analogue of natural squamosamide Homo sapiens
3.4.24.81 formononentin
-
 Homo sapiens
3.4.24.81 furin
-
 Homo sapiens
3.4.24.81 G-protein-coupled purinergic receptor
-
 Homo sapiens
3.4.24.81 gintonin
-
 Homo sapiens
3.4.24.81 glucagon-like peptide-1 receptor
-
 Homo sapiens
3.4.24.81 ion channel purinergic receptor
-
 Homo sapiens
3.4.24.81 metallothionein III
-
 Homo sapiens
3.4.24.81 nardilysin
-
 Homo sapiens
3.4.24.81 pituitary adenylate cyclase-activating polypeptide receptor
-
 Homo sapiens
3.4.24.81 synapse-associated protein 97
-
 Homo sapiens
3.4.24.81 tetraspanin 12
-
 Homo sapiens
3.4.24.81 tetraspanin 27
-
 Homo sapiens
3.4.24.81 tetraspanin 28
-
 Homo sapiens
3.4.24.81 tetraspanin 29
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.81 Q170H the mutation in the pro-domain region of the ADAM10 gene reduce alpha-secretase activity of the enzyme Homo sapiens
3.4.24.81 R181G the mutation in the pro-domain region of the ADAM10 gene reduce alpha-secretase activity of the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.81 GI254023X specific inhibitor Homo sapiens
3.4.24.81 nerve growth factor
-
 Homo sapiens
3.4.24.81 Rapamycin
-
 Homo sapiens
3.4.24.81 RECK
-
 Homo sapiens
3.4.24.81 Sfrp
-
 Homo sapiens
3.4.24.81 TIMP-1
-
 Homo sapiens
3.4.24.81 TIMP-3
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.81 beta-amyloid precursor protein + H2O Homo sapiens cleavage at Lys683-Leu684 sAPP-alpha fragment + C-terminal fragment
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.81 Homo sapiens O14672
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.81 blood platelet
-
 Homo sapiens
-
3.4.24.81 HEK-293 cell
-
 Homo sapiens
-
3.4.24.81 hippocampus
-
 Homo sapiens
-
3.4.24.81 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.81 beta-amyloid precursor protein + H2O cleavage at Lys683-Leu684 Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.81 a disintegrin and metalloproteinase 10
-
 Homo sapiens
3.4.24.81 AD10
-
 Homo sapiens
3.4.24.81 ADAM10
-
 Homo sapiens
3.4.24.81 CD156c
-
 Homo sapiens
3.4.24.81 HsT18717
-
 Homo sapiens
3.4.24.81 kuz
-
 Homo sapiens
3.4.24.81 MADM
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.81 0.0000001
-
 TIMP-1 pH and temperature not specified in the publication Homo sapiens
3.4.24.81 0.0000009
-
 TIMP-3 pH and temperature not specified in the publication Homo sapiens
3.4.24.81 0.000005
-
 GI254023X pH and temperature not specified in the publication Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.81 physiological function the enzyme is directly involved in the development of Alzheimer's disease, prion diseases, fragile X syndrome and possibly Huntington disease Homo sapiens