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Literature summary extracted from

  • Abrahao, M.V.; Dos Santos, N.F.T.; Kuwabara, W.M.T.; do Amaral, F.G.; do Carmo Buonfiglio, D.; Peres, R.; Vendrame, R.F.A.; Flavio da Silveira, P.; Cipolla-Neto, J.; Baltatu, O.C.; Afeche, S.C.
    Identification of insulin-regulated aminopeptidase (IRAP) in the rat pineal gland and the modulation of melatonin synthesis by angiotensin IV (2019), Brain Res., 1704, 40-46 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.3 Insulin insulin activates the enzyme migration from the intracellular vesicles to the cellular membrane Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.3 angiotensin IV AngIV, induces an increase in the intracellular calcium concentration in pinealocytes by 72% at 10 nM, but AngIV does not alter cAMP levels Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.3 cell membrane enzyme IRAP is localized in intracellular vesicles which can translocate to the cell membrane under insulin stimulation Rattus norvegicus
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3.4.11.3 vesicle enzyme IRAP is localized in intracellular vesicles which can translocate to the cell membrane under insulin stimulation Rattus norvegicus 31982
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Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.3 Zn2+ IRAP is a zinc-dependent aminopeptidase Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.3 oxytocin + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.11.3 Vasopressin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.3 Rattus norvegicus P97629
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.3 astrocyte
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 Rattus norvegicus
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3.4.11.3 basal ganglion
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 Rattus norvegicus
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3.4.11.3 brain AT4 receptor/IRAP is found in neurons in the cortex, hippocampus and basal ganglia Rattus norvegicus
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3.4.11.3 brain cortex
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 Rattus norvegicus
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3.4.11.3 heart
-
 Rattus norvegicus
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3.4.11.3 hippocampus
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 Rattus norvegicus
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3.4.11.3 neuron
-
 Rattus norvegicus
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3.4.11.3 pineal gland
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 Rattus norvegicus
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3.4.11.3 pinealocyte
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.3 oxytocin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.11.3 Vasopressin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.3 AT4 receptor
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 Rattus norvegicus
3.4.11.3 insulin-regulated aminopeptidase
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 Rattus norvegicus
3.4.11.3 IRAP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.11.3 evolution IRAP is a type-2 membrane glycoprotein from the M1 family of zinc-dependent aminopeptidases Rattus norvegicus
3.4.11.3 physiological function the AT4 receptor identified as the IRAP is found in neurons in the cortex, hippocampus and basal ganglia. The presence of aminopeptidases A and N in the pineal gland suggests local production of Ang IV that could act through its specific receptor (IRAP)/AT4 to modulate melatonin synthesis, analysis of the role of enzyme inhibitor Ang IV on melatonin synthesis using isolated pinealocyte cultures, overview. IRAP is an enzyme that is mostly associated with cellular membranes, and its translocation appears to be regulated by insulin, which activates its migration from the intracellular vesicles to the cellular membrane together with the glucose transporter, Glut4. IRAP plays either the role of a true receptor, the (IRAP)/AT4 receptor, inducing intracellular signaling pathways, or the role of an enzyme that metabolizes several peptides, such as oxytocin and arginine vasopressin Rattus norvegicus