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Literature summary extracted from

  • Lipitsae, T.; Siiskonen, H.; Naukkarinen, A.; Harvima, I.T.
    Mast cell chymase degrades fibrinogen and fibrin (2019), Br. J. Dermatol., 181, 296-303 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.39 heparin heparin enhances the degradation of the beta-chain of fibrinogen Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.39 medicine the fibrinolytic enzyme with anticoagulative properties may aid in the clearance of fibrin from vessel walls in aged vasculitis lesions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.39 complement component C3 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 complement component C3a + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 Fibrin + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 fibrinogen + H2O Homo sapiens chymase degrades the alpha-, beta- and gamma-chains of fibrinogen, while heparin enhances the degradation of the beta-chain fibrin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 complement component C3 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 complement component C3a + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 Fibrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 fibrinogen + H2O chymase degrades the alpha-, beta- and gamma-chains of fibrinogen, while heparin enhances the degradation of the beta-chain Homo sapiens fibrin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.39 mast cell chymase
-
 Homo sapiens