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Literature summary extracted from

  • Ge, X.; Yamaguchi, Y.; Zhao, L.; Bury, L.; Gresele, P.; Berube, C.; Leung, L.L.; Morser, J.
    Prochemerin cleavage by factor XIa links coagulation and inflammation (2018), Blood, 131, 353-364 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.27 thrombin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.27 PN-2
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.27 0.000103
-
 prochemerin chem163S at pH 7.4 and 37°C Homo sapiens
3.4.21.27 0.3
-
 factor IX 10-mer at pH 7.4 and 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.27 Ca2+ 5 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.27 factor IX + H2O Homo sapiens
-
 activated factor IX + ?
-
 ?
3.4.21.27 prochemerin chem163S + H2O Homo sapiens prochemerin is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin forms with different levels of activity chemerin chem162R + chermerin chem158K
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.27 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.27 D-LPRANSNH-C3H7 + H2O
-
 Homo sapiens D-LPR + ANSNH-C3H7
-
 ?
3.4.21.27 factor IX + H2O
-
 Homo sapiens activated factor IX + ?
-
 ?
3.4.21.27 factor IX 10-mer + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.27 prochemerin chem163S + H2O prochemerin is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin forms with different levels of activity Homo sapiens chemerin chem162R + chermerin chem158K
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.27 factor XIa
-
 Homo sapiens
3.4.21.27 FXIa
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.27 0.083
-
 factor IX 10-mer at pH 7.4 and 37°C Homo sapiens
3.4.21.27 0.91
-
 prochemerin chem163S at pH 7.4 and 37°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.4.21.27 17
-
 factor IX 10-mer at pH 7.4 and 37°C Homo sapiens
3.4.21.27 530000
-
 prochemerin chem163S at pH 7.4 and 37°C Homo sapiens