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Literature summary extracted from

  • Rose, J.A.; Lahiri, S.D.; McKinney, D.C.; Albert, R.; Morningstar, M.L.; Shapiro, A.B.; Fisher, S.L.; Fleming, P.R.
    Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase (2015), Bioorg. Med. Chem. Lett., 25, 3301-3306 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.11.18 in complex with inhibitor N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide Escherichia coli
3.4.11.18 molecular docking of inhibitor N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide and comparison with docking in Escherichia coli structure Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.18 N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
-
 Escherichia coli
3.4.11.18 N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
-
 Haemophilus influenzae
3.4.11.18 N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
-
 Staphylococcus aureus
3.4.11.18 N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
-
 Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.18 Escherichia coli P0AE18
-
-
3.4.11.18 Haemophilus influenzae
-
-
-
3.4.11.18 Staphylococcus aureus
-
-
-
3.4.11.18 Streptococcus pneumoniae
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.11.18 MAP
-
 Staphylococcus aureus
3.4.11.18 MAP
-
 Haemophilus influenzae
3.4.11.18 MAP
-
 Streptococcus pneumoniae
3.4.11.18 MAP
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.18 0.03
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
3.4.11.18 0.046
-
 pH not specified in the publication, temperature not specified in the publication Streptococcus pneumoniae N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
3.4.11.18 0.06
-
 pH not specified in the publication, temperature not specified in the publication Haemophilus influenzae N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
3.4.11.18 0.2
-
 value above 0.2 mM, pH not specified in the publication, temperature not specified in the publication Staphylococcus aureus N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide