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Literature summary extracted from

  • Balomenou, S.; Koutsioulis, D.; Tomatsidou, A.; Tzanodaskalaki, M.; Petratos, K.; Bouriotis, V.
    Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus (2018), Bioorg. Med. Chem., 26, 3845-3851 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.1.104 crystal structure analysis of Zn-bound enzyme Bacillus cereus
3.5.1.104 crystal structure analysis of Zn-bound enzyme Bacillus anthracis

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.104 additional information construction of Bacillus anthracis 7702 DELTAba1977 mutant strain Bacillus anthracis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.104 1-naphthoxyhydroxamic acid
-
 Bacillus anthracis
3.5.1.104 1-naphthoxyhydroxamic acid
-
 Bacillus cereus
3.5.1.104 3-biphenylhydroxamic acid
-
 Bacillus anthracis
3.5.1.104 3-biphenylhydroxamic acid
-
 Bacillus cereus
3.5.1.104 N-hydroxy-3-phenoxybenzamide
-
 Bacillus anthracis
3.5.1.104 N-hydroxy-3-phenoxybenzamide
-
 Bacillus cereus
3.5.1.104 N-hydroxy-4-(naphthalene-1-yl)benzamide
-
 Bacillus anthracis
3.5.1.104 N-hydroxy-4-(naphthalene-1-yl)benzamide a potent competitive inhibitor; a potent competitive inhibitor Bacillus cereus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.104 0.0048
-
 (GlcNAc)5 pH 6.8, 22°C Bacillus cereus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.104 Zn2+ a zinc metalloenzyme Bacillus cereus
3.5.1.104 Zn2+ a zinc metalloenzyme Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.104 Bacillus anthracis A0A2B6CE99
-
-
3.5.1.104 Bacillus anthracis A0A2P0HD08
-
-
3.5.1.104 Bacillus cereus Q81EJ6
-
-
3.5.1.104 Bacillus cereus Q81EK9
-
-
3.5.1.104 Bacillus cereus ATCC 14579 Q81EJ6
-
-
3.5.1.104 Bacillus cereus ATCC 14579 Q81EK9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.104 (GlcNAc)5 + H2O
-
 Bacillus cereus ?
-
 ?
3.5.1.104 (GlcNAc)5 + H2O
-
 Bacillus cereus ATCC 14579 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.104 BA1961
-
 Bacillus anthracis
3.5.1.104 BA1977
-
 Bacillus anthracis
3.5.1.104 BC1960
-
 Bacillus cereus
3.5.1.104 Bc1974
-
 Bacillus cereus
3.5.1.104 BC_1960
-
 Bacillus cereus
3.5.1.104 BC_1974
-
 Bacillus cereus
3.5.1.104 peptidoglycan GlcNAc deacetylases
-
 Bacillus cereus
3.5.1.104 peptidoglycan GlcNAc deacetylases
-
 Bacillus anthracis
3.5.1.104 peptidoglycan N-acetylglucosamine deacetylase
-
 Bacillus cereus
3.5.1.104 peptidoglycan N-acetylglucosamine deacetylase
-
 Bacillus anthracis
3.5.1.104 pgdA_1
-
 Bacillus anthracis
3.5.1.104 pgdA_2
-
 Bacillus anthracis
3.5.1.104 PGNGdacs
-
 Bacillus cereus
3.5.1.104 PGNGdacs
-
 Bacillus anthracis
3.5.1.104 polysaccharide deacetylase
-
 Bacillus cereus
3.5.1.104 polysaccharide deacetylase
-
 Bacillus anthracis
3.5.1.104 yheN
-
 Bacillus anthracis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.104 22
-
 assay at room temperature Bacillus cereus
3.5.1.104 37
-
 assay at Bacillus anthracis
3.5.1.104 50
-
-
 Bacillus cereus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.1.104 3000
-
 (GlcNAc)5 pH 6.8, 22°C Bacillus cereus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.104 6
-
-
 Bacillus cereus
3.5.1.104 6.8
-
-
 Bacillus cereus
3.5.1.104 7.3
-
 assay at Bacillus anthracis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.104 additional information
-
 additional information inhibition kinetic analysis Bacillus cereus
3.5.1.104 additional information
-
 additional information inhibition kinetic analysis Bacillus anthracis
3.5.1.104 0.0087
-
 N-hydroxy-4-(naphthalene-1-yl)benzamide pH 6.8, 22°C Bacillus cereus
3.5.1.104 0.066
-
 N-hydroxy-4-(naphthalene-1-yl)benzamide pH 6.0, 50°C Bacillus cereus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.104 0.0433
-
 pH 6.8, 22°C Bacillus cereus N-hydroxy-4-(naphthalene-1-yl)benzamide
3.5.1.104 0.132
-
 pH 6.0, 50°C Bacillus cereus N-hydroxy-4-(naphthalene-1-yl)benzamide

General Information

EC Number General Information Comment Organism
3.5.1.104 additional information sequence comparisons of the PGNGdacs BC1960, BA1961, BC1974 and BA1977 from Bacillus cereus and Bacillus anthracis Bacillus cereus
3.5.1.104 additional information sequence comparisons of the PGNGdacs BC1960, BA1961, BC1974 and BA1977 from Bacillus cereus and Bacillus anthracis Bacillus anthracis