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Literature summary extracted from

  • Zahov, S.; Garzinsky, D.; Hanekamp, W.; Lehr, M.
    1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase Studies on structure-activity relationships and metabolic stability (2017), Bioorg. Med. Chem., 25, 825-837 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.99 1-(1H-benzimidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[(3'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[(3'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[(4'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]pentan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-imidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-imidazo[4,5-b]pyridin-1-yl)-3-(4-octylphenoxy)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(1H-indazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(3H-imidazo[4,5-b]pyridin-3-yl)-3-(4-octylphenoxy)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(1H-1,2,4-triazol-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(1H-pyrazol-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(1H-pyrazolo[3,4-b]pyridin-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(1H-pyrazolo[4,3-b]pyridin-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(2H-1,2,3-triazol-2-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-(4-octylphenoxy)-3-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
-
 Homo sapiens
3.5.1.99 1-[([1,1'-biphenyl]-4-yl)oxy]-3-(1H-tetrazol-1-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)butan-2-one
-
 Homo sapiens
3.5.1.99 1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)propan-2-one
-
 Homo sapiens
3.5.1.99 3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
-
 Homo sapiens
3.5.1.99 3-(1H-benzotriazol-1-yl)-1-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
 Homo sapiens
3.5.1.99 3-[([1,1'-biphenyl]-4-yl)oxy]-1-(1H-tetrazol-1-yl)butan-2-one
-
 Homo sapiens
3.5.1.99 3-[([1,1'-biphenyl]-4-yl)oxy]-1-(2H-tetrazol-2-yl)butan-2-one
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.99 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.99 N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.99 FAAH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.99 0.0000029
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
3.5.1.99 0.000009
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 3-[([1,1'-biphenyl]-4-yl)oxy]-1-(2H-tetrazol-2-yl)butan-2-one
3.5.1.99 0.000011
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[(3'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
3.5.1.99 0.000011
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)propan-2-one
3.5.1.99 0.000012
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]butan-2-one
3.5.1.99 0.000012
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
3.5.1.99 0.000012
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]propan-2-one
3.5.1.99 0.000013
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)propan-2-one
3.5.1.99 0.000013
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
3.5.1.99 0.000013
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
3.5.1.99 0.000014
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[(3'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
3.5.1.99 0.000015
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-(4-octylphenoxy)propan-2-one
3.5.1.99 0.000019
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 3-[([1,1'-biphenyl]-4-yl)oxy]-1-(1H-tetrazol-1-yl)butan-2-one
3.5.1.99 0.000021
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[(4'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
3.5.1.99 0.000039
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one
3.5.1.99 0.000043
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-[([1,1'-biphenyl]-4-yl)oxy]-3-(1H-tetrazol-1-yl)propan-2-one
3.5.1.99 0.000049
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)propan-2-one
3.5.1.99 0.000053
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(1H-1,2,4-triazol-1-yl)propan-2-one
3.5.1.99 0.00006
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
3.5.1.99 0.000093
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(1H-pyrazolo[4,3-b]pyridin-1-yl)propan-2-one
3.5.1.99 0.000112
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(2H-1,2,3-triazol-2-yl)propan-2-one
3.5.1.99 0.00041
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(3H-imidazo[4,5-b]pyridin-3-yl)-3-(4-octylphenoxy)propan-2-one
3.5.1.99 0.00041
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-imidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
3.5.1.99 0.00048
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzimidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
3.5.1.99 0.00062
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-imidazo[4,5-b]pyridin-1-yl)-3-(4-octylphenoxy)propan-2-one
3.5.1.99 0.00063
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 3-(1H-benzotriazol-1-yl)-1-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
3.5.1.99 0.00084
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(1H-pyrazol-1-yl)propan-2-one
3.5.1.99 0.0016
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(4-octylphenoxy)-3-(1H-pyrazolo[3,4-b]pyridin-1-yl)propan-2-one
3.5.1.99 0.0018
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]pentan-2-one
3.5.1.99 0.0023
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-(1H-indazol-1-yl)-3-(4-octylphenoxy)propan-2-one
3.5.1.99 0.0063
-
 37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Homo sapiens 1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)butan-2-one