EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.1 | 2-(2,6-difluorophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(2,6-dimethoxyphenyl)-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 2-(2-bromophenyl)-4H-3,1-benzoxazin-4-one | competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one | competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(2-thienyl)-4H-3,1-benzoxazin-4-one | competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3,4,5-trimethoxyphenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3-bromophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3-bromophenyl)-7-nitro-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3-chlorophenyl)-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 2-(3-chlorophenyl)-7-methyl-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3-fluorophenyl)-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one | competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3-methylphenyl)-7-nitro-4H-3,1-benzoxazin-4-one | competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(4-bromophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(4-fluorophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 2-phenyl-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 4-methyl-N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]benzenesulfonamide | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 7-chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | mixed-type inhibition | Bos taurus | |
3.4.21.1 | 7-chloro-2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 7-chloro-2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | 7-chloro-2-phenyl-4H-3,1-benzoxazin-4-one | non-competitive inhibition | Bos taurus | |
3.4.21.1 | benzoxazinone | the presence of substituents on benzene ring reduces the inhibitory potential of benzoxazinone. The increased inhibitory potential due to fluoro group at phenyl substituent is observed followed by chloro and bromo substituents. Compounds with strong electron donating or withdrawing groups on phenyl substituent, show a good inhibitory potential at ortho > meta > para position. Kinetic studies show diverse types of inhibition, except uncompetitive-type inhibition | Bos taurus | |
3.4.21.1 | chymostatin | competitive inhibition | Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.1 | Bos taurus | P00766 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.1 | pancreas | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.1 | N-succinyl-L-phenylalanine-p-nitroanilide + H2O | - |
Bos taurus | N-succinyl-L-phenylalanine + p-nitroaniline | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.1 | alpha-chymotrypsin | - |
Bos taurus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.1 | 0.00047 | - |
2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0026 | - |
chymostatin | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0087 | - |
2-phenyl-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0091 | - |
2-(2-thienyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0091 | - |
2-(2-bromophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0098 | - |
2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0125 | - |
2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0126 | - |
2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0161 | - |
2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.01619 | - |
2-(3-methylphenyl)-7-nitro-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0164 | - |
2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0178 | - |
2-(3-fluorophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0224 | - |
2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0226 | - |
2-(3-chlorophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0277 | - |
2-(2,6-dimethoxyphenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.0301 | - |
2-(2,6-difluorophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.094 | - |
2-(4-fluorophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.303 | - |
7-chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus | |
3.4.21.1 | 0.341 | - |
2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one | pH 7.6, 30°C | Bos taurus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.21.1 | 0.0058 | - |
pH 7.6, 30°C | Bos taurus | chymostatin | |
3.4.21.1 | 0.0065 | - |
pH 7.6, 30°C | Bos taurus | 2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0099 | - |
pH 7.6, 30°C | Bos taurus | 2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0117 | - |
pH 7.6, 30°C | Bos taurus | 2-phenyl-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0121 | - |
pH 7.6, 30°C | Bos taurus | 2-(2-thienyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0144 | - |
pH 7.6, 30°C | Bos taurus | 2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0188 | - |
pH 7.6, 30°C | Bos taurus | 2-(2-bromophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0201 | - |
pH 7.6, 30°C | Bos taurus | 2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0235 | - |
pH 7.6, 30°C | Bos taurus | 2-(2,6-difluorophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0238 | - |
pH 7.6, 30°C | Bos taurus | 2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0239 | - |
pH 7.6, 30°C | Bos taurus | 2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0263 | - |
pH 7.6, 30°C | Bos taurus | 2-(2,6-dimethoxyphenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0282 | - |
pH 7.6, 30°C | Bos taurus | 2-(3-fluorophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0288 | - |
pH 7.6, 30°C | Bos taurus | 2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0418 | - |
pH 7.6, 30°C | Bos taurus | 2-(3-chlorophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.0941 | - |
pH 7.6, 30°C | Bos taurus | 2-(3-methylphenyl)-7-nitro-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.159 | - |
pH 7.6, 30°C | Bos taurus | 2-(4-fluorophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.314 | - |
pH 7.6, 30°C | Bos taurus | 2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one | |
3.4.21.1 | 0.329 | - |
pH 7.6, 30°C | Bos taurus | 7-chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one |