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Literature summary extracted from

  • Holmes, R.S.; Barron, K.A.; Krupenko, N.I.
    Ceramide synthase 6 comparative analysis, phylogeny and evolution (2018), Biomolecules, 8, 111 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Mus musculus the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Homo sapiens the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Gallus gallus the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Danio rerio the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides an ultra-long-chain ceramide + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.298 Danio rerio A0A140LFW4
-
-
2.3.1.298 Gallus gallus F1N8P2
-
-
2.3.1.298 Homo sapiens Q8IU89
-
-
2.3.1.298 Mus musculus Q1A3B0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.298 skin
-
 Mus musculus
-
2.3.1.298 skin
-
 Homo sapiens
-
2.3.1.298 skin
-
 Gallus gallus
-
2.3.1.298 skin
-
 Danio rerio
-
2.3.1.298 testis
-
 Mus musculus
-
2.3.1.298 testis
-
 Homo sapiens
-
2.3.1.298 testis
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides Mus musculus an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides Homo sapiens an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides Gallus gallus an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base the enzyme exhibits a broad acyl chain preference synthesizing C26-C32 acyl chain ceramides Danio rerio an ultra-long-chain ceramide + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.298 ? x * 45066, calculated from amino acid sequence Danio rerio
2.3.1.298 ? x * 45302, calculated from amino acid sequence Gallus gallus
2.3.1.298 ? x * 46081, calculated from amino acid sequence Mus musculus
2.3.1.298 ? x * 46316, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.298 CerS3
-
 Mus musculus
2.3.1.298 CerS3
-
 Homo sapiens
2.3.1.298 CerS3
-
 Gallus gallus
2.3.1.298 CerS3
-
 Danio rerio

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.3.1.298 Danio rerio calculated from amino acid sequence
-
 7.2
2.3.1.298 Homo sapiens calculated from amino acid sequence
-
 7.6
2.3.1.298 Mus musculus calculated from amino acid sequence
-
 8.3
2.3.1.298 Gallus gallus calculated from amino acid sequence
-
 8.9